Effect of Virus on Host Cell Flashcards
How do viruses interfere with cell membrane function
Promote cell fusion
Affect ion exchange and membrane potential
Induce synthesis of intracellular membranes
Damage cytoskeleton
Mechanism of Acutely Transforming RNA virus
- Infection of cell with retrovirus and inetegration of proto-oncogene
- Mutation causes proto-oncogene to become oncogene
- Infection of new host cell
- Integration and expresson of viral oncogene
- Neoplastic transformation
Differentiation Antigens
Proteins associated with specific stages of cell differentiation
Neoplasia
Denotes an abnormal tissue overgrowth that may be either localized or disseminated it is the process that leads to the formation of neoplasms
Tumor Specific Antigens
Products of mutated oncogenes and tumor suppressor genes
All RNA tumor viruses belong to the family
Retroviridae
Most important oncogenic viruses in animals?
Retroviruses
Responsible for degradation of the cells own DNA and proteins during apoptosis
Caspases
Primary effect of virus on the host cell is due to
Viral replication and viral proteins that are toxic to the host cell
Oncogenic Papillomaviruses
Produce papillomas on the skin and mucous membranes of most animal species
Hyperplastic epithelial outgrowths that generally regress spontaneously
Acutely Transforming RNA Virus
Directly oncogenic by carring an additional viral oncogene (V-onc)
Examples of cytopathic effects
Cell lysis
Cell rounding
Cell detachment
Vacuoles in cytoplasm
Inclusion bodies
Syncytium formation
Antigenic changes in cell membrane
Swelling and clumping
Pyknosis
Degenerative condition of a cell nucleus marked by clumping of the chromosomes, hyper chromatism and shrinking of the nucleus
Membrane Fusion/ Surface Fusion only occurs in (enveloped/nonenveloped) viruses
Enveloped
Cytotoxic T lymphocytes and NK cells can initiate extrinsic apoptotsis pathway utilizing medatos such as
Perforin and Granzyme
Host cell genes that encode important cell signaling products that regulate normal cell proliferation
C-onc genes and Proto-oncogenes
Non cytocidal viruses typically cause ___________ infections.
Non cytocidal viruses typically cause persistant infections.
Oncogenic viruses
Viruses that cause or give rise to tumors
Oncogenes
Mutated forms of proto-oncogenes or aberrantly expressed proto-oncogenes
Types of Tumor Antigens
Differentiation Antigens
Mutated Proteins
Viral Coded Proteins
Excessive Amounts of Normal Protein
Cancer/Testis Antigens
DNA tumor viruses interact with the cell in what two ways
Productive infection in permissive cell resulting in cell lysis
Non productive infection in nonpermissive cell resulting in transformation of the cell
Benign Neoplasm
Growth produced by abnormal cell proliferation that remains localized and does not invade adjacent tissue
Cell Fusion
Syncytium or Polykaryon
Fusion of the plasma membrane of four or more cells to produce an enlarged cell with four or more nuclei