Retroviridae Flashcards
Pro genes of retroviruses encode
Protease
Characteristics of Deltaretroviruses
Complex
Type C Morphology
Gag, Pro, Pol, Env, rex and tex - Gag, Pro and Pol presented in 3 different reading frames
Exogenous
Feline Immunodeficiency Virus (FIV) belongs to what genus of retroviruses
Lentivirus
Type C Retrovirus
Assemble at plasma membrane and contain central symmetrically placed spherical inner core
Most common form of avian leukosis of chickens 4-30 weeks old
Lymphoid Leukosis
Retroviruses that cause chronic transformation do so by
Insertion/mutation through random integration into the genome of the host
Retroviruses that infect chickens belong to what retrovirus groups
Alpharetrovirus
Gammaretrovirus
Incubation period of FIV
Long incubation period - may last as long as 6 years
Characteristics of Betaretroviruses
Simple
Type B or Type D morphology
Assembled in cytoplasm via Type A intermediate
Gag, Pro, Pol, Env - Gag, Pro and Pol in different reading frames
Endogenous and Exogenous
Main determinant of FeLV pathogenicity
Surface Glycoprotein
Retrovirus virions are resistent to
Ultraviolet or X-rays
How do insects transmitt Equine Infectious Anemia Virus
When feeding fly is interrupted it will fly to another horse and transmit the virus
Gag gene of retroviruses encode
Virus core proteins: capsid, nucleocapsid, matrix
Secondary effects of thrombocytopenia seen with what retrovirus?
Equine Infectious Anemia Virus
Lymphoid Leukosis
Pale combs or cyanotic
Nodular lesions in teh bursa fabricuiuc containing B lymphocytes
Shape and position of the core was used to classify retroviruses into what categories
Type A - Type D
Equine infectious anemia virus - Swamp Fever - is transmitted through
Blood
Secretions
Insects
Disease caused by what retrovirus?
Erythroblastosis
Avian Retrovirus
Viral oncogenes undergo transformation to remove
regulatory mechanisms
FIV replicates in what cells
Lymphocytes mostly CD4+ T cells, B cells and macrophages
Characteristics of Lentiviruses
Complex
Cylindrical or Conical Shaped Core
Gag, Pro, Pol, Env, Vif, Vpr, Vpo, Tat, Rev and Nef - Gag separate from Pol and Pro in same reading frame
Exogenous
Characteristics of Gammaretroviruses
Simple
Type C morphology
Gag, Pol, Pro, Env - Gag, Pro, Pol in same reading frame
Endogenous and Exogenous
Endogenous gammaretroviruses
Endogenous Feline Leukemia Virus (enFeLV)
RD114 Virus
FIV is transmitted by
Deep bite wounds and scratches
Characteristics of Retroviruses
Enveloped
Budd from cell membrane
Single Stranded
+ Sense RNA
Diagnose FeLV
p27 ELISA
Immunofluorescence Assay (IF)
Virus isolation in cell culture
FeLV subtype T
Tropism for T lymphocytes
FeLV is shed from an infected cat through
Saliva
Nasal Secretions
Feces
Milk
Oncogenic genes of avian retroviruses are transmitted
Horizontally or vertically through infectious virus or provirus integrated into host germ cell DNA