Flaviviridae Flashcards
Classical Swine Fever virus is transmitted by
Oronasal route
Infection with BVDV can result in what clinically different disease syndromes
Bovine Viral Diarrhea
Mucosal Disease
Genera of Flaviviridae
Flavivirus
Pestivirus
Hepacivirus
Diagnosis of BVDV
Clinical history and signs
Virus isolation in cell culture
Diagnosis of Classical Swine Fever
Clinical Signs
Characteristics of chronic mucosal disease
Skin ulcers, areas of hyperkeratosis and necrosis of crypt enterocytes
West Nile Virus is maintained in
Mosquitos and Birds
Characteristics of postnatal BVDV infection in non-pregnant cattle
Most common in young animals
Milid clinical disease
Biphasic fever, leukopenia, diarrhea, ulceration on lips/mouth/oral cavity, decreased milk production, thrombocytopenia
Clinical sign of what disease pattern of BVDV
Chronic mucosal disease
Diagnosis of West Nile Virus
IgM ELISA
Cytopathic BVDV
Induce cytopathic effect in infected cells
Non Cytopathic BVDV
Cause persistent infection
Characteristics of BVBD infection in pregnant cows
Transplacental spread to fetus
Disease depends on fetus age:
- Early- embryonic death/reabsorption
- Before Immunological Competence - destructive fetal lesions, persistent postnatal infection, retarded growth “weak calf syndrome”, congenital defects
- Late- carriers of virus, seronegative.
Clinical signs of West Nile Virus
Various Neurological Signs
Fever
Abnormal Gait
Head tremors
Muscle Fasciculation
Ataxia
Recumbance
Mucosal Disease caused by BVDV
Sporadic disease occuring in persistently infected animals, usually as an aftermath of an epizootic infection
Bovine Viral Diarrhea Virus (BVDV) belong to the genus
Pestivirus
Pathogenesis of BVDV mucosal disease
Develop after infection with both non-cytopathic and cytopathic biotypes
Virus replicates throughout the GI tract and lymph nodes
Erosion or ulcers in mucosal epitheilum
Clinical sign of what disease pattern of BVDV
Post natal infection in non pregnant cattle
Bovine Viral Diarrhea
Acute disease, epizootic in nature in naive animals
Primary replication site of Classical Swine Fever Virus
Tonsils
Clinical signs of what Flavivirus
Classical Swine Fever Virus
Lineages of West Nile Virus
WNV 1 and WNV 2
Characteristics of persistant BVDV infection in calves and mucosal disease
Caused by non cytopathic virus
Failure to thrive
Mucosal disease develops when co-infected with cytopathic virus
Secondary site of replication for Classical Swine Fever Virus
Lymphoid Tissue
Clinical features of Classical Swine Fever Virus
Diffuse hyperemia, nervous system signs, lethargy, paralysis, tremors and convulsions
Transmission of BVDV
Indirectly
Directly from persistently infected animals
BVDV mucosal disease is manifested by
Fever, anorexia, profuse watery diarrhea, erosion or ulcerative stomatitis
Flaviviruses are inactivated by
Heat, common disinfectants, lipid solvents
Clinical signs of what disease pattern of BVDV
Persistent infection in calves and mucosal disease
Disease patterns arising for BVDV infection
Postnatal infection in non-pregnant cattle
Infection in pregnant cows
Persistent infection in calves and mucosal disease
Replication of Flaviviruses occurs in the
Cytoplasm
West Nile Virus is fatal in what species
Birds
Pathogenesis of postnatal BVDV infection
Respiratory
Replication in nasal mucosa and tonsils to lymph nodes and then to intestines
West Nile Virus belongs to genus
Flavivirus
Characterisistics of Flavivirus
Enveloped
Single Stranded RNA
Positive Sense
Infectious RNA
