Rh Blood Group System

Question 1

1. The Rh system genes are:
   a. RHD and RHCE.
   b. RHD and LW.
   c. RHD and RHAG.
   d. RHCE and RHAG.

Answer 1

a. RHD and RHCE.

Question 2

2. What Rh antigen is found in 85% of the Caucasian population and is always significant for transfusion purposes?
   a. d
   b. c
   c. D
   d. E

Answer 2

c. D

Question 3

3. How are weaker-than-expected reactions with anti-D
   typing reagents categorized?
   a. Rhmod
   b. Weak D
   c. DAT positive
   d. Dw

Answer 3

b. Weak D

Question 4

4. Cells carrying a weak D antigen require the use of what
   test to demonstrate its presence?
   a. Indirect antiglobulin test
   b. Direct antiglobulin test
   c. Microplate test
   d. Warm autoadsorption test

Answer 4

a. Indirect antiglobulin test

Question 5

5. How are Rh antigens inherited?
   a. Autosomal recessive alleles
   b. Sex-linked genes
   c. Codominant alleles
   d. X-linked

Answer 5

c. Codominant alleles

Question 6

6. Biochemically speaking, what type of molecules are Rh
   antigens?
   a. Glycophorins
   b. Simple sugars
   c. Proteins
   d. Lipids

Answer 6

c. Proteins

Question 7

7. Rh antibodies react best at what temperature (°C)?
   a. 15
   b. 18
   c. 22
   d. 37

Answer 7

d. 37

Question 8

8. . Rh antibodies are primarily of which immunoglobulin
   class?
   a. IgA
   b. IgD
   c. IgG
   d. IgM

Answer 8

c. IgG

Question 9

9. Rh antibodies have been associated with which clinical
   condition?
   a. Hemolytic disease of the fetus and newborn
   b. Thrombocytopenia
   c. Hemophilia A
   d. Stomatocytosis

Answer 9

a. Hemolytic disease of the fetus and newborn

Question 10

10. What do Rhnull cells lack?
    a. Lewis antigens
    b. Normal oxygen-carrying capacity
    c. Rh antigens
    d. Hemoglobin

Answer 10

c. Rh antigens

Question 11

11. Convert the following genotypes from Wiener nomenclature to Fisher-Race and Rosenfield nomenclatures,
    and list the antigens present in each haplotype.
    a. R1r
    b. R2R0
    c. RzR1
    d. r’r

Question 12

12. Which Rh phenotype has the strongest expression of D?
    a. DCe/ce
    b. DCe/DCe
    c. DcE/DcE
    d. D–

Answer 12

d. D–

Question 13

13. An individual has the following serologic reactions:

D+C+E+c+e+f–. What is the most probable genotype?

Answer 13

a. R1R2

Question 14

14. Which of the following is the most common haplotype
    in the African American population?
    a. DCe
    b. DcE
    c. Dce
    d. ce

Answer 14

c. Dce

Question 15

15. If a patient who is R1R1 is transfused with RBCs that are Ror, which antibody is he most likely to produce?

a. Anti-D
b. Anti-c
c. Anti-e
d. Anti-G

Answer 15

b. Anti-c