Autoimmune Hemolytic Anemias Flashcards
1
Q
- Immune hemolytic anemias may be classified in which of
the following categories?
a. Alloimmune
b. Autoimmune
c. Drug-induced
d. All of the above
A
d. All of the above
2
Q
- When preparing cells for a cold autoadsorption procedure, it is helpful to pretreat the cells with which of the
following?
a. Dithiothreitol
b. Ficin
c. Phosphate-buffered saline at pH 9
d. Bovine albumin
A
b. Ficin
3
Q
- The blood group involved in the autoantibody specificity
in PCH is:
a. P.
b. ABO.
c. Rh.
d. Lewis.
A
a. P.
4
Q
- Which of the following blood groups reacts best with an
anti-H or anti-IH?
a. O
b. B
c. A2
d. A1
A
a. O
5
Q
- With cold-reactive autoantibodies, the protein coating
the patient’s cells and detected in the DAT is:
a. C3.
b. IgG.
c. C4.
d. IgM.
A
a. C3.
6
Q
- Problems in routine testing caused by cold-reactive
autoantibodies can usually be resolved by all of the
following except:
a. Prewarming.
b. Washing with warm saline.
c. Using anti-IgG antiglobulin serum.
d. Testing clotted blood specimens
A
d. Testing clotted blood specimens
7
Q
- Pathological cold autoagglutinins differ from common
cold autoagglutinins in:
a. Immunoglobulin class.
b. Thermal amplitude.
c. Antibody specificity.
d. DAT results on EDTA specimen.
A
b. Thermal amplitude.
8
Q
- Cold AIHA is sometimes associated with infection by:
a. Staphylococcus aureus.
b. Mycoplasma pneumoniae.
c. Escherichia coli.
d. Group A Streptococcus
A
b. Mycoplasma pneumoniae.
9
Q
- Many warm-reactive autoantibodies have a broad specificity within which of the following blood groups?
a. Kell.
b. Duffy.
c. Rh.
d. Kidd.
A
c. Rh.
10
Q
- Valid Rh typing can usually be obtained on a patient
with WAIHA using all of the following reagents or techniques except:
a. Slide and modified tube anti-D.
b. Chloroquine-treated RBCs.
c. Rosette test.
d. Monoclonal anti-D.
A
a. Slide and modified tube anti-D.
11
Q
- In pretransfusion testing for a patient with WAIHA, the
primary concern is:
a. Treating the patient’s cells with chloroquine for reliable antigen typing.
b. Adsorbing out all antibodies in the patient’s serum to
be able to provide compatible RBCs.
c. Determining the exact specificity of the autoantibody
so that compatible RBCs can be found.
d. Discovering any existing significant alloantibodies in
the patient’s circulation
A
d. Discovering any existing significant alloantibodies in
the patient’s circulation
12
Q
- Penicillin given in massive doses has been associated
with RBC hemolysis. Which of the classic mechanisms
is typically involved in the hemolytic process?
a. Immune complex.
b. Drug adsorption.
c. Membrane modification.
d. Autoantibody formation.
A
b. Drug adsorption.
13
Q
- Which of the following drugs has been associated
with complement activation and rapid intravascular
hemolysis?
a. Penicillins.
b. Quinidine.
c. Alpha-methyldopa.
d. Cephalosporins
A
d. Cephalosporins
14
Q
- A patient is admitted with a hemoglobin of 5.6 g/dL. Initial
pretransfusion workup appears to indicate the presence of
a warm autoantibody in the serum and coating his RBCs.
His transfusion history indicates that he received 6 units
of RBCs 2 years ago after an automobile accident. Which
of the following would be most helpful in performing
antibody detection and compatibility testing procedures?
a. Adsorb the autoantibody using the patient’s enzymetreated cells.
b. Perform an elution and use the eluate for compatibility
testing.
c. Crossmatch random units until compatible units are
found.
d. Collect blood from relatives who are more likely to
be compatible.
A
a. Adsorb the autoantibody using the patient’s enzymetreated cells.
15
Q
- A patient who is taking Aldomet has a positive DAT. An
eluate prepared from his RBCs would be expected to:
a. React only with Aldomet-coated cells.
b. Be neutralized by a suspension of Aldomet.
c. React with all normal cells.
d. React only with Rhnull cells.
A
c. React with all normal cells.
