Cellular therapy in the hematopoietic Transplant setting

Question 1

1. When an HPC donor is unrelated to the recipient of an
   HPC transplantation, the transplant is categorized as:
   a. Allogeneic
   b. Autologous
   c. Syngeneic
   d. Hematopoietic

Answer 1

a. Allogeneic

Question 2

2. Stem cells from HPC donors may be mobilized with:
   a. Plerixafor
   b. Filgrastim (GCSF)
   c. Chemotherapy
   d. All of the above

Answer 2

d. All of the above

Question 3

3. Which is an advantage of an HPC transplant using umbilical cord blood as the HPC source?
   a. Recipient weight of no concern
   b. Donor screening and testing abbreviated
   c. Higher risk of GVHD
   d. No significant risk to the donor or mother

Answer 3

d. No significant risk to the donor or mother

Question 4

4. The recommended minimum number of CD34+ cells required in an HPC-apheresis collection to ensure timely
   engraftment is:
   a. 2 × 102 CD34+ cells/kg
   b. 2 × 104 CD34+ cells/kg
   c. 2 × 106 CD34+ cells/kg
   d. 2 × 108 CD34+ cells/kg

Answer 4

c. 2 × 106 CD34+ cells/kg

Question 5

5. The cellular marker used to quantify the collection of
   HPCs using flow cytometry is:
   a. CD4
   b. CD33
   c. CD34
   d. CD59

Answer 5

c. CD34

Question 6

6. An A patient received an HPC transplant from a B donor.
   What type of ABO mismatch does this represent?
   a. Major
   b. Minor
   c. Bidirectional
   d. Any of the above

Answer 6

c. Bidirectional

Question 7

7. Which of the following terms describe an HPC transplant where donor and recipient are the same person?
   a. Allogeneic
   b. Autologous
   c. Syngeneic
   d. Hematopoietic

Answer 7

b. Autologous

Question 8

8. Three weeks after sustaining a car accident that required
   emergency transfusion of blood products for resuscitation, an allogeneic HPC transplant recipient developed
   a fever, erythematous skin rash, diarrhea, and cytopenias, which ultimately were fatal. What intervention
   may have prevented this outcome?
   a. The use of leukoreduced blood products
   b. The use of irradiated of blood products
   c. The use of CMV-negative blood products
   d. The use of washed blood products

Answer 8

b. The use of irradiated of blood products

Question 9

9. What common cryoprotectant is added to HPC products
   for freezing?
   a. Dimethyl sulfoxide
   b. Polyethylene glycol
   c. Glycerol
   d. Normal saline

Answer 9

a. Dimethyl sulfoxide

Question 10

10. An O patient received an HPC transplant from a B donor.
    What type of ABO mismatch does this represent?
    a. Major
    b. Minor
    c. Bidirectional
    d. Any of the above

Answer 10

a. Major