Blood Group : Lewis, P, I, MNS, Kell, Duffy, Kidd, Lutheran

Question 1

1. The following phenotypes are written incorrectly except
   for:
   a. Jka+
   b. Jka+
   c. Jka(+)
   d. Jk(a+)

Answer 1

d. Jk(a+)

Question 2

2. Which of the following characteristics best describes
   Lewis antibodies?
   a. IgM, naturally occurring, cause HDFN
   b. IgM, naturally occurring, do not cause HDFN
   c. IgG, in vitro hemolysis, cause hemolytic transfusion
   reactions
   d. IgG, in vitro hemolysis, do not cause hemolytic transfusion reactions

Answer 2

b. IgM, naturally occurring, do not cause HDFN

Question 3

3. The Le gene codes for a specific glycosyltransferase that
   transfers a fucose to the N-acetylglucosamine on:
   a. Type 1 precursor chain
   b. Type 2 precursor chain
   c. Types 1 and 2 precursor chains
   d. Either type 1 or type 2 in any one individual but not
   both

Answer 3

a. Type 1 precursor chain

Question 4

4. What substances would be found in the saliva of a group
   B secretor who also has Lele genes?
   a. H, Lea
   b. H, B, Lea
   c. H, B, Lea, Leb
   d. H, B, Leb

Answer 4

c. H, B, Lea, Leb

Question 5

5. Transformation to Leb phenotype after birth may be as
   follows:
   a. Le(a–b–) to Le(a+b–) to Le(a+b+) to Le(a–b+)
   b. Le(a+b–) to Le(a–b–) to Le(a–b+) to Le(a+b+)
   c. Le(a–b+) to Le(a+b–) to Le(a+b+) to Le(a–b–)
   d. Le(a+b+) to Le(a+b–) to Le(a–b–) to Le(a–b+)

Answer 5

a. Le(a–b–) to Le(a+b–) to Le(a+b+) to Le(a–b+)

Question 6

6. In what way do the Lewis antigens change during
   pregnancy?
   a. Lea antigen increases only
   b. Leb antigen increases only
   c. Lea and Leb both increase
   d. Lea and Leb both decrease

Answer 6

d. Lea and Leb both decrease

Question 7

7. A type 1 chain has:
   a. The terminal galactose in a 1-3 linkage to subterminal
   N-acetylglucosamine
   b. The terminal galactose in a 1-4 linkage to subterminal
   N-acetylglucosamine
   c. The terminal galactose in a 1-3 linkage to subterminal
   N-acetylgalactosamine
   d. The terminal galactose in a 1-4 linkage to subterminal
   N-acetylgalactosamine

Answer 7

a. The terminal galactose in a 1-3 linkage to subterminal
N-acetylglucosamine

Question 8

8. Which of the following best describes Lewis antigens?
   a. The antigens are integral membrane glycolipids
   b. Lea and Leb are antithetical antigens
   c. The Le(a+b–) phenotype is found in secretors
   d. None of the above

Answer 8

d. None of the above

Question 9

10. Anti-LebH will not react or will react more weakly with
    which of the following RBCs?
    a. Group O Le(b+)
    b. Group A2 Le(b+)
    c. Group A1 Le(b+)
    d. None of the above

Answer 9

c. Group A1 Le(b+)

Question 10

9. Which of the following genotypes would explain RBCs typed as group A Le(a+b–)?
   a. A/O Lele HH Sese
   b. A/A Lele HH sese
   c. A/O LeLe hh SeSe
   d. A/A LeLe hh sese

Answer 10

b. A/A Lele HH sese

Question 11

11. Which of the following best describes MN antigens and
    antibodies?
    a. Well developed at birth, susceptible to enzymes, generally saline reactive
    b. Not well developed at birth, susceptible to enzymes,
    generally saline reactive
    c. Well developed at birth, not susceptible to enzymes,
    generally saline reactive
    d. Well developed at birth, susceptible to enzymes, generally antiglobulin reactive

Answer 11

a. Well developed at birth, susceptible to enzymes, generally saline reactive

Question 12

12. Which autoantibody specificity is found in patients with
    paroxysmal cold hemoglobinuria?
    a. Anti-I
    b. Anti-i
    c. Anti-P
    d. Anti-P1

Answer 12

c. Anti-P

Question 13

13. Which of the following is the most common antibody
    seen in the blood bank after ABO and Rh antibodies?
    a. Anti-Fya
    b. Anti-k
    c. Anti-Jsa
    d. Anti-K

Answer 13

d. Anti-K

Question 14

14. Which blood group system is associated with resistance
    to P. vivax malaria?
    a. P
    b. Kell
    c. Duffy
    d. Kidd

Answer 14

c. Duffy

Question 15

15. The null Ko RBC can be artificially prepared by which
    of the following treatments?
    a. Ficin and DTT
    b. Ficin and glycine-acid EDTA
    c. DTT and glycine-acid EDTA
    d. Glycine-acid EDTA and sialidase

Answer 15

c. DTT and glycine-acid EDTA

Question 16

16. Which antibody does not fit with the others with respect
    to optimum phase of reactivity?
    a. Anti-S
    b. Anti-P1
    c. Anti-Fya
    d. Anti-Jkb

Answer 16

b. Anti-P1

Question 17

17. Which of the following Duffy phenotypes is prevalent
    in blacks but virtually nonexistent in whites?
    a. Fy(a+b+)
    b. Fy(a–b+)
    c. Fy(a–b–)
    d. Fy(a+b–)

Answer 17

c. Fy(a–b–)

Question 18

18. Antibody detection cells will not routinely detect which
    antibody specificity?
    a. Anti-M
    b. Anti-Kpa
    c. Anti-Fya
    d. Anti-Lub

Answer 18

b. Anti-Kpa

Question 19

19. Antibodies to antigens in which of the following blood
    groups are known for showing dosage?
    a. I
    b. P
    c. Kidd
    d. Lutheran

Answer 19

c. Kidd

Question 20

20. Which antibody is most commonly associated with
    delayed hemolytic transfusion reactions?
    a. Anti-s
    b. Anti-k
    c. Anti-Lua
    d. Anti-Jka

Answer 20

d. Anti-Jka

Question 21

21. Anti-U will not react with which of the following RBCs?
    a. M+N+S+s–
    b. M+N–S–s–
    c. M–N+S–s+
    d. M+N–S+s+

Answer 21

b. M+N–S–s–

Question 22

22. A patient with an M. pneumoniae infection will most
    likely develop a cold autoantibody with specificity to
    which antigen?
    a. I
    b. i
    c. P
    d. P1

Answer 22

a. I

Question 23

23. Which antigen is destroyed by enzymes?
    a. P1
    b. Jsa
    c. Fya
    d. Jka

Answer 23

c. Fya