Apheresis

Question 1

1. The most common anticoagulant used for apheresis
   procedures is:
   a. Heparin
   b. Sodium fluoride
   c. Warfarin
   d. Citrate

Answer 1

d. Citrate

Question 2

2. Therapeutic cytapheresis has a primary role in treatment
   of patients with:
   a. Sickle cell disease and acute chest syndrome
   b. Systemic lupus erythematosus to remove immune
   complexes
   c. Leukemia to help increase granulocyte production
   d. Myasthenia gravis to increase antibody production

Answer 2

a. Sickle cell disease and acute chest syndrome

Question 3

3. The minimum interval allowed between plateletpheresis
   component collection procedures is:
   a. 1 day
   b. 2 days
   c. 7 days
   d. 8 weeks

Answer 3

b. 2 days

Question 4

4. In plasma exchange, the therapeutic effectiveness is:
   a. Greatest with the first plasma volume removed
   b. Affected by the type of replacement fluid used
   c. Enhanced if the unwanted antibody is IgG rather than
   IgM
   d. Independent of the use of concomitant immunosuppressive therapy

Answer 4

a. Greatest with the first plasma volume removed

Question 5

5. The replacement fluid indicated during plasma exchange
   for TTP is:
   a. Normal (0.9%) saline
   b. Hydroxyethyl starch (HES)
   c. FFP
   d. Albumin (human) 5%

Answer 5

c. FFP

Question 6

6. The most common adverse effect of plateletpheresis collection is:
   a. Allergic reaction
   b. Hepatitis
   c. Hemolysis
   d. Citrate effect

Answer 6

d. Citrate effect

Question 7

7. Apheresis technology can be used to collect each of the
   following components except:
   a. Leukocytes
   b. Macrophages
   c. Hematopoietic progenitor cells
   d. Platelets

Answer 7

b. Macrophages

Question 8

8. The anticoagulant added to blood as it is removed from a
   donor or patient during an apheresis procedure acts by:
   a. Binding calcium ions
   b. Increasing intracellular potassium
   c. Binding to antithrombin III
   d. Inactivating factor V

Answer 8

a. Binding calcium ions

Question 9

9. Peripheral blood stem cells are:
   a. Responsible for phagocytosis of bacteria
   b. Removed during erythrocytapheresis
   c. Pluripotential hematopoietic precursors that circulate
   in the peripheral blood
   d. Lymphocytes involved with the immune response

Answer 9

c. Pluripotential hematopoietic precursors that circulate

Question 10

10. Which of the following can be given to an apheresis donor
    to increase the number of circulating granulocytes?
    a. DDAVP
    b. Hydroxyethyl starch (HES)
    c. Immune globulin
    d. G-CSF

Answer 10

d. G-CSF