Review of Immune System/Autoimmune Diseases (REVISE)

Question 1

Antigens targeted in Lupus

Answer 1

Double stranded DNA

Question 2

Cells targeted in Type I Diaebete’s

Answer 2

Islet Cells

Question 3

Antigens targeted in Myasthenia Gravis

Answer 3

ACh Receptors

Question 4

Antigens targeted in Multiple Sclerosis

Answer 4

Myelin Sheath of Nerve Fibres

Question 5

What does a B cell bind to and what does a T cell bind to

Answer 5

Question 6

How is there such a variety of antibodies even though we only have a total of 22,000 genes

Answer 6

Our genome has many gene segments that encode for antibodies which rearrange and recombine to form a massive array of different antibodies on lymphocytes

Question 7

Why does autoimmunity occur

Answer 7

We physiologically always develop lymphocytes that recognise ‘self’ cells

There is an issue with the regulation of this self recognition that causes autoimmunity

Question 8

Self Tolerance

Answer 8

The ability of the immune system to recognize - and therefore not respond against - self-produced antigens

Question 9

Describe Central Tolerance

Answer 9

The process of eliminating any developing T or B lymphocytes that are reactive to self

REVISE

Question 10

ADD TO REST OF LECTURE