Respiratory System Exam Notes Flashcards

1
Q

Write a note on the anatomy of the trachea.

3

A

Extends from the sixth cervical vertebra to the fifth
thoracic vertebra. (C6-T5)

A tough, flexible tube running from the larynx to the bronchi

In the MEDIASTINUM the trachea ends at the CARINA
and branches into the two primary bronchi

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2
Q

Write a note on the histology of the trachea.

3

A

Ciliated pseudostratified columnar epithelium with goblet cells

Held open by C-shaped tracheal cartilages in submucosa

Trachealis muscle present = smooth muscle.

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3
Q

Write a note on the functions of the trachea.

2

A

Provide a clear airway for air to enter and exit the lungs.

The epithelium lining the trachea produces mucus that traps dust and other contaminants and prevents it from reaching the lungs.

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4
Q

Write a note on the anatomy of the lung.

6

A

2 lungs

Left lung has two lobes

Right lung has three lobes

Lobes of the lung are separated by fissures.

Each lobe is a sealed unit.

Hilum = area of lung where all blood vessels, nerves and the bronchi enter/leave
the lung

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5
Q

Write a note on the anatomy of the Bronchi.

3

A

Trachea branches at the carina into two tubes = right and left bronchi.

Bronchi enter the lungs at the hilum of each lung

Branch into secondary bronchus which supplies air to each lobe of the lung and branches into tertiary bronchi

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6
Q

Write a note on the histology of the bronchi.

5

A

Lumen – airflow

Epithelium – ciliated pseudostratified columnar epithelium with goblet cells

Smooth muscle layer – bronchodilation to allow airflow, bronchoconstriction to decrease airflow

Submucosal glands – produce secretions

Cartilage – protects bronchus, helps keep it open

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7
Q

Write a note on the functions of bronchi.

3

A

Carry air to and from your lungs

Help moisten the air you breathe

Help screen out foreign particles

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8
Q

Write a note on the anatomy of the bronchiole.

4

A

Airways with a diameter of less than 1mm
Three types:
-small bronchiole
-terminal bronchiole (last airway without alveoli)
-respiratory bronchiole (first airway with alveoli)

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9
Q

Write a GENERAL note on the histology of the bronchiole (points relevant to all three types).
(3)

A

Lack cartilage

Have smooth muscle

Different types of cuboidal epithelium (e,g. tall, simple, ciliated)

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10
Q

Write a note on the histology of a small bronchiole.

4

A

Lumen

Ciliated tall cuboidal epithelium

Band of smooth muscle

Some supporting connective tissue around the edge

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11
Q

Write a note on the histology of a respiratory bronchiole.

2

A

Simple cuboidal epithelium with alveoli interspersed amongst

Gives rise to alveolar ducts (tubes consisting of side-by-side alveoli which give rise to alveolar sacs - dead ends consisting of nothing but alveoli)

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12
Q

Write a note on the anatomy of the alveolar region.

5

A

Acinar region

Parenchymal region

Respiratory exchange surfaces (alveoli walls) are connected to circulatory system via pulmonary circuit

Alveolar wall - must be thin - contains pulmonary capillaries

Alveolar airspace - must remain open

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13
Q

Write a note on the histology of the alveoli walls

5

A

Simple squamous epithelium - type 1 cells - structure to wall - transport and removal of fluid via pumps - cannot divide when damaged

Endothelial cells found in pulmonary capillaries in walls

Fused basal laminae between alveoli for efficient gas diffusion

Type 2 cells - produce surfactant - keep alveoli open - reduce surface tension - twice as abundant as type 1 - replace type 1

Alveolar macrophages - engulf foreign particles

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14
Q

Write a note on the diaphragm

4

A

A sheath of muscle that extends across the bottom of the thoracic cavity

A rectus muscle - skeletal muscle fibres running longitudinally

Contracts and moves down during inhalation which causes the volume of the thoracic cavity to increase which pulls air into the lung

Relaxes and returns to its curved position during exhalation which causes the volume of the thoracic cavity to decrease which pushes air out of the lung

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15
Q

Write a note on the rectus abdominus.

3

A

Long flat muscle
extending the length of the abdomen

Compresses the ribs
and abdomen

It plays a role in respiration in the event of shortness of breath

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16
Q

Define Henry’s Law

A

At a given temperature amount of a gas in solution is proportional to partial pressure of that gas

17
Q

Define Boyle’s Law

A

Pressure and volume have an inverse relationship

18
Q

How does oxygen diffuse between blood and alveolus?

3

A

Concentration of gases is not equal between the two -> there is a concentration gradient

Causes a diffusion of CO2 from blood to alveolus to be breathed out

And causes diffusion of O2 from alveolus into blood

19
Q

Write a note on macromolecules that aid gas diffusion.

A

Soaplike, consisting of phospholipid and protein,
they coat the inner surface of the Alveolus. (e.g.
Surfactant – produced by Type 2 Pneumocytes)

20
Q

Write a note on haemoglobin and how it aids gas diffusion.

4

A

Red coloured protein found in rbcs

Has four binding sites for O2

Binding to heme forms oxyhaemoglobin

Four chains - 2 a and 2 b with a heme attached to each (an iron atom at centre of each heme)

21
Q

Write a note on carbon dioxide transport.

7

A

Most CO2 enters the rbc by diffusing through the plasma membrane (this stops H+ affecting plasma)

23% of this CO2 bind to haemoglobin to form carbaminohaemoglobin

The rest is converted into a hydrogen ion and a bicarbonate ion

CO2+ H+ H2O ↔ H2CO3 ↔ H+ + HCO3−

Bicarbonate ions diffuse back out into the plasma

Hydrogen ions bind to protein of haemoglobin (=> doesn’t affect pH)

This is reversed when rbcs reach lungs

22
Q

Explain the carbon dioxide transport equation

A

Carbon dioxide (CO2) combines with water forming carbonic acid, which dissociates into a hydrogen ion (H+) and a bicarbonate

CO2+ H2O ↔ H2CO3 ↔ H+ + HCO3−

23
Q

Daltons Law

A

the total pressure of a mixture of gases is equal to the sum of the partial pressures of the individual component gases