RESPIRATORY SYSTEM Flashcards

1
Q

how long can a human survive without breathing?

A

3 minutes

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2
Q

the respiratory system can be divided into the?

A

conducting zone: part of the respiratory system that includes organs that provide passageways for air and are not directly involved in gas exchange.
respiratory zone: includes structures of the respiratory system that are directly involved in gas exchange.

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3
Q

major function of the conducting zone?

A

provide route for incoming and outgoing air, remove debris and pathogens from the air, humidify the air, sensing odours.

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4
Q

the major entrance and exit for the respiratory system is through the?

A

nose and some air also enters through the oral cavity.

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5
Q

large particles such as dirt is removed from the air by?

A

the hairs as it enters the external nares(nostrils) of the nose and flows into the nasal cavity.

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6
Q

what do the conchae of the nasal cavity do?

A

increase surface area for air filtration and humidification and warm and moisten air.

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7
Q

what is the nasal cavity lined with?

A

ciliated columnar epithelium and goblet cells that produce mucus to trap debris. cilia of the epithelium clear mucus.

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8
Q

where does air exit the nasal cavity from?

A

internal nares and moves into the pharynx.

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9
Q

what is the pharynx and what is it divided into and what is it formed by?

A

the pharynx is a tube formed by skeletal muscle. it is divided into 3 major regions: nasopharynx, oropharynx, and the laryngopharynx.

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10
Q

what is the nasopharynx function?

A

serves only as an airway.

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11
Q

what do the oropharynx and laryngopharynx do?

A

passageway for both air and food. at the bottom end of the laryngopharynx, the digestive and respiratory systems diverge.

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12
Q

what does the anterior side and posterior side of the laryngopharynx open into?

A

anterior side: larynx
posterior side: esophagus

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13
Q

what is the larynx?

A

cartilaginous structure inferior to the laryngopharynx. it connects the pharynx to the trachea.
- regulates the volume of air that enters and leaves the lungs.

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14
Q

what are the 3 cartilage pieces the larynx is made of?

A

thyroid cartilage: adams apple
epiglottis: covers opening of the trachea to make sure food and drink dont enter.
cricoid cartilage

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15
Q

what is a trachea?

A

the trachea is the windpipe that extends from the larynx to the lungs. it is formed by 16-20 stacked c shaped pieces of hyaline cartilage.

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16
Q

what does the trachea branch into?

A

the trachea branches into right and left primary bronchi.
- primary bronchi enter the lungs and then each primary bronchus branches into a secondary bronchus and then into a tertiary bronchus.
- primary, secondary, and tertiary bronchi are referred to as the brochial tree,

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17
Q

what is the function of bronchi?

A

provide a passageway for air to move into and out of each lung.

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18
Q

what branches off of the tertiary bronchi?

A

bronchioles are 1mm in diameter, branch from the tertiary bronchi. bronchioles branch into terminal bronchioles which lead to the structures of gas exchange.

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19
Q

how many terminal bronchioles are in each lung?

A

over 1000 terminal bronchioles in each lung.

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20
Q

the respiratory zone begins when?

A

the respiratory zone begins when the terminal bronchioles join the respiratory bronchiole which then leads to an alveolar duct which then leads to alveolar sac which then leads to alveoli.

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21
Q

what is an alveoli/alveolus?

A

one of the many sacs in the alvoelar sac responsible for gas exchange.
- they have elastic walls that allow the alveolus to stretch which increases the surface area.
- they are connected to other alveoli with alveolar pores.

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22
Q

what tissues make up the alveolar wall?

A

simple squamous epithelial cells.
- attached to basement membrane.
- attached to capillary membrane.
- respiratory membrane allows gases to cross via simple diffusion.

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23
Q

what is the anatomy of the lungs?

A
  • connect to the trachea by right and left bronchi.
  • under the lungs is the diaphragm.
  • the lungs are enclosed by the pleura.
  • the right lung is shorter and wider than the left lung and the left lung occupies less volume to make space for the heart.
  • each lung is composed of smaller units called lobes.
    RIGHT LUNG: superior, middle, inferior
    LEFT LUNG: superior, inferior
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24
Q

what is the pleura of the lungs?

A

each lung is surrounded by the pleura.
the pleura has 2 layers: visceral pleura(connects to lungs) and parietal pleura(connects to diaphragm and thoracic wall).
- between the visceral and parietal layers is the pleural cavity.

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25
Q

what are the two major functions of the pleura?

A
  • produce pleural fluid and to create cavities that separate the major organs.
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26
Q

what is the function of pleural fluid?

A
  • lubricates surfaces to reduce friction.
  • causes the lungs to enlarge to be able to fill with air.
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27
Q

what is the major mechanisms that drive pulmonary ventilation?

A

atmospheric pressure: Patm
air pressure within alveoli called intra-alveolar pressure: Palv
pressure within pleural cavity: intrapleural pressure: Pip

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28
Q

What is atmospheric pressure?

A

the pressure exerted by the air around our bodies.
- 760 mmHG
- negative pressure is lower than atmospheric pressure.
- positive pressure is greater than atmospheric pressure.
- pressure equal to atmospheric pressure is 0.

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29
Q

what is intra-alveolar pressure?

A

pressure of the air within the alveoli and it changes during different phases of breathing.
- since the alveoli are connected to the atmosphere via tubing of airways, the intra-alveolar pressure always equalizes with the atmospheric pressure.

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30
Q

what is intrapleural pressure?

A

pressure of air within the pleural cavity and it changes during different phases of breathing.
- the intrapleural pressure always remains lower than/negative to the intraalveolar pressure by 4mmHg.

31
Q

what is boyle’s law?

A

if volume increases, pressure decreases.
if volume decreases, pressure increases.

32
Q

what drives pulmonary ventilation?

A

air flows down a pressure gradient.
air flows from an area of higher pressure to an area of lower pressure. air flows into the lungs due to difference in pressure. atmospheric pressure is higher than intra-alveolar pressure and that is greater than intrapleural pressure.

33
Q

what are the major steps in pulmonary ventilation and describe them?

A

inspiration: process that causes air to enter the lungs
expiration: process that causes the air to leave the lungs

34
Q

what is a respiratory cycle?

A

one sequence of inspiration and exhalation.

35
Q

what muscle groups are used during normal inspiration?

A

diaphragm and external intercostal muscles.
during contraction diaphragm goes downwards and during contraction external intercostal muscles move the ribs outwards INCREASES VOLUME.
increase in volume means the pressure decreases. this pressure gradient drives air into the lungs.

36
Q

what is the process of normal expiration like?

A
  • passive process.
  • diaphragm and external intercostal muscles relax
  • decrease in volume increasing pressure.
  • increase in intrapulmonary pressure over atmospheric pressure causes air to leave the lungs.
37
Q

eupnea vs diaphragmatic breathing vs hyperpnea vs costal breathing?

A

eupnea: quiet breathing
diaphragmatic breathing: deep breath
costal breathing: shallow breath
hyperpnea: forced breathing

38
Q

the control of ventilation is from what region of the brain primarily?

A

brainstem that signal the muscles used in pulmonary ventilation to contract.

39
Q

what is respiratory rate? whats the normal respiratory rate for children under 1, child whos 10, and adults?

A

total number of breaths or respiratory cycles that occur each minute.
children under 1: 30-60
child whos 10: 18-30
adolescence/adults: 12-18

40
Q

what is the dorsal respiratory group DRG?

A

region of the medulla oblongata that stimulates the contraction of the diaphragm and intercostal muscles to induce inspiratoin.

41
Q

what is ventral respiratory group VRG?

A

region of the medulla oblongata that stimulate the contraction of muscles involved in respiration for FORCED inspiration/expiration

42
Q

where is the second respiratory centre of the brain and what does it consist of?

A
  • located in the pons
  • called pontine respiratory group
  • apneustic and pneumotaxic centres.
43
Q

what is apneustic vs pneumotaxic?

A

apneustic centre: network of neurons within the pons that stimulate the neurons in drg. CONTROLS DEPTH OF INSPIRATION
pneumotaxic centre: network of neurons within the pons that inhibit the activity of the neurons in drg. CONTROLS RATE OF BREATHING

44
Q

what is the main driver of breathing changes?

A

carbon dioxide. co2 levels make blood more acidic due to more hydrogen ions.
also low oxygen levels.

45
Q

what else affects breathing rate?

A

central chemoreceptors: located in brain: detect changes in blood acidity.
peripheral chemoreceptors: located in carotid arteries/aortic arch: monitor blood levels of co2, o2, acidity.

46
Q

what does the cerebral cortex do for controlling the rate of breathing?

A

override automatic breathing for activities like singing or holding breath.

47
Q

what does the hypothalamus and limbic system do for controlling rate of breathing?

A

adjust breathing based on emotions, pain, or temperature changes.

48
Q

what are the 4 types of respiratory volumes?

A

tidal, residual, inspiratory reserve, and expiratory reserve.

49
Q

what is tidal volume?

A

amount of air that normally enters the lungs during quiet breathing which is about 500ml.

50
Q

what is expiratory reserve volume?

A

the amount of air you can forcefully exhale past a normal tidal expiration. up to 1200ml

51
Q

what is inspiratory reserve volume?

A

maximum amount of air you can inhale in after a breath. 3000ml

52
Q

what is residual volume?

A

amount of air left in the lungs if you exhale as much air as possible. this prevents the alveoli from collapsing.

53
Q

what is respiratory capacity?

A

combination of two or more selected volumes: total amount of air that the lungs can hold during breathing.

54
Q

what is total lung capacity?

A

sum of all lung volumes: TV+ERV+IRV+RV
6000ml for men and 4200ml for women

55
Q

what is vital capacity?

A

amount of air a person can move into our out of his/her lungs. sum of all volumes except residual volume.

56
Q

what is inspiratory capacity?

A

tidal volume and inspiratory reserve volume.

57
Q

what is the functional residual capacity?

A

expiratory reserve volume and residual volume

58
Q

what is anatomical dead space?

A

air that is present in the airway that doesnt reach the alveoli or participate in gas exchange.

59
Q

what is alveolar dead space?

A

air found within the alveoli that are unable to function.

60
Q

what is total dead space?

A

anatomical dead space and alveolar dead space combined representing all of the air not being used in the gas exchange process

61
Q

what is partial pressure?

A

force exerted by each gas in a mixture of gases

62
Q

what is total pressure?

A

sum of all the partial pressures in a gaseous mixture aka daltons law.

63
Q

the greater the partial pressure difference between two areas…

A

the more rapid is the movement of gases.

64
Q

gas exchange occurs at two sites in the body, what are they?

A
  • lungs: external respiration
  • tissues: internal respiration
65
Q

what is oxyhemoglobin?

A

formed when oxygen molecules bind to hemoglobin in a red blood cell. bright red.

66
Q

higher temperature promotes?

A

hemoglobin and oxygen to dissociate faster.

67
Q

lower more acidic pH PROMOTES?

A

oxygen dissociation from hemoglobin.

68
Q

carbon dioxide is transported by 3 major mechanisms?

A
  1. blood plasma
  2. bicarbonate
  3. carbaminohemoglobin
69
Q

talk about how co2 is transported in blood plasma?

A

dissolved co2 travels into the bloodstream and when blood reaches the pulmonary capillaries, the dissolved co2 diffuses across the respiratory membrane into the alveoli where it is then exhaled during pulmonary ventilation.
- 7-10%

70
Q

talk about how bicarbonate helps in co2 transport?

A

-70%
- large portion of co2 molecules diffuse into the blood are transported to the lungs as bicarbonate.
- carbon dioxide combined with water to form carbonic acid which splits into bicarbonate and hydrogen ions.
bicarbonate moves from rbc into blood
the bicarbonate turns back into co2 and water and is then moved into the alveoli to be exhaled.

71
Q

talk about how carbaminohemoglobin is used to transport co2?

A
  • 20%
  • carbon dioxide binds to the amino acid on the protein parts of hemoglobin to form carbaminohemoglobin.
  • blueish-purple
  • once it reaches the lungs it detaches from hemoglobin and is exhaled.
72
Q

what is hyperventilation and why does it happen?

A

rapid breathing: decreases co2 levels in the blood.
reasons it can happen:
- abnormal lung functioning from asthma or emphysema.
- high altitudes where partial pressure of oxygen decreases.
- infection or fever

73
Q

what does low co2 levels in the blood do?

A

alkalosis when the blood plasma pH is higher than normal. also decreases blood pressure.

74
Q

what is hypoxia?

A

reduction in the amount of oxygen reaching the tissues.
- deficiency in atmospheric oxygen.
- hemoglobin deficiency from anemia
- edema
hypoxia can result in cyanosis or tachycardia