Respiratory Flashcards

1
Q

The conducting system of the respiratory tract induces?

A
Nasal cavity 
Paranasal sinus
Larynx
Trachea 
Bronchi
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2
Q

What system of the respiratory system is made of only bronchioles, lined by Clara cells

A

Transitional system

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3
Q

What system of the respiratory tracts is made of alveoli and pulmonary capillaries?

A

Exchange system

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4
Q

T/F: bronchioles have goblet cells

A

False

A healthy individual should not have these or very few

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5
Q

What type of epithelial cells are found in alveoli?

A
Type I (membranous) 
Type II (granular) pneumocytes
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6
Q

The bronchial arteries carry (oxygenated/deoxygenated) blood to the lungs

A

Oxygenated

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7
Q

what bacteria of normal flora is commonly found in cattle and can cause shipping fever?

A

Mannheimia haemolytica

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8
Q

T/F: bordetella brochispetica can be found as a normal commenal of the lower respiratory tract

A

False

Lower respiratory tract is considered sterile (no normal flora there)
This can be found as a normal flora of the upper resp tract

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9
Q

Are the the non-immune mediated defense mechanisms of the respiratory tract?

A

Mucous trapping
Mucociliary
Phagocytosis
Air turbulence (coughing or sneezing)

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10
Q

What species are intravasular macrophages found in?

A

Ruminant
Cat
Pig
Horse

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11
Q

In dogs, rodents, and humans, what cells are responsible form removing circulating bacteria or particles?

A

Kupffer cells (liver) or splenic macrophages

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12
Q

What is commonly the cause of epistaxis in old horses?

A

Ethmoidal hematoma

Other causes:
Trauma
Exercised induces
Mycotic infection of the guttural pouch

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13
Q

A fibrinous rhinitis and formation of a diptheritic membrane in a calf is due to ???

A

Infectious bovine rhiotracheitis (bovine herpesvirus 1)

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14
Q

What parasite of sheep can be found in the nasal cavity of sheep, sometimes penetrating the into the sinuses or brain cavity?

A

Oestrus ovis (nasal bot)

Commonly see mucous/catarrhal rhinitis
Neurological disease

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15
Q

PM of pig

Atrophy of nasal turbinates and deviated nasal septum

Disease name and etiology?

A

Atopic rhinitis

Bordetella brochispetica > toxin against osteoblasts
Pasteurella multocidia > toxin against osteoclast

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16
Q

What is the etiology of inclusion body rhinitis?

A

Porcine cytomegalovirus (suid herpesvirus 2)

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17
Q

What are two viruses of cats causing rhinotracheitis ?

A
Feline herpesvirus 1 
Feline calicivirus (usually with vesicles/ulcers on tongue)
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18
Q

Feline calicivirus can cause what conditions ?

A

Conjunctivitis
Rhinotracheitis
Ulcerative/vesicular stomatitis
Diffuse interstitial pneumonia

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19
Q

What fungal organisms of dogs can produce a granulomatous rhinitis in the nasal mucosa?

A

Rhinosporidium seeberi

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20
Q

What do you call trapped air in the guttural pouch?

A

Guttural pouch tympany - usually due to a malformation of the distal end of the Eustachian tube

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21
Q

Horse with .. enlarged guttural pouch and lymph nodes, along with supperative exudate from lesions along the jaw lien

A

Strangles - streptococcus equi

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22
Q

What nerves and arteries are we concerned about in Stranges?

A

Internal carotid artery > erosion of the artery wall can lead to epistaxis or fatal hemorrhage

CN IV, IX, X, XI, and XII

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23
Q

What is often the etiologic agent of guttural pouch mycosis ?

A

Aspergillus

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24
Q

What stains are used to visualize fungal infections?

A

PAS (periodic acid shiff)

GMS (Gomori’s methenamine silver)

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25
Q

Enzootic nasal carcinoma is found in what species and is caused by what?

A

Sheep

Ovine beta-retrovirus (enzootic nasal tumor virus)

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26
Q

What is the most likely etiology of calf diphtheria ?

A

Infectious bovine rhinotracheitis (bovine herpesvirus 1)

Followed by secondary infection of fusobacterium necrophorum

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27
Q

Horse

Roaring sound???

A

Neuropathy of the left recurrent laryngeal nerve -> atrophy of the dorsal cricoarytenoid muscle

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28
Q

What is the cause of tracheal collapse?

Who is this mainly seen in?

A

Widening of the cartilaginous rings causes flattening of the dorsal ligament of the trachea

Miniature/toy dog breeds
Occasionally horse, cattle, and goat

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29
Q

Etiology of fibronecrtozing laryngotracheitis in cattle?

A

infectous bovine rhinotracheitis

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30
Q

What lesions can be seen in a systemic herpesvirus infection in a claf?

A

Ulcerative and necrotizing lesions in the rumen

Foci of necrotic hepatitis

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31
Q

What is the primary pathogen of kennel cough?

A

Bordetella brochispetica

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32
Q

Horse

Head and neck are extended
Nasal flaring
Mucous nasal discharge
Heave line

A

Recurrent airway obstruction

Clinical signs caused by resistance to airflow/ diffuse bronchoconstriction

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33
Q

Mucous in the airway (bronchioles) of a horse is called ________ ,and in a feline is __________

A

Recurrent airway obstruction

Feline asthma/feline allergic bronchitis/ hyperactive airway disease

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34
Q

The blood air barrier is composed of?

A

Vascular endothelium
BM of endothelial cells
BM of type I pneumocytes and its cytoplasm

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35
Q

Hemorrhage in the dorsal caudal portion of the caudal lungs lobes of a race horse

A

Most likely exercise-induced pulmonary hemorrhage

Elevation in arterial and capillary pressures during strenuous exercise

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36
Q

What is the sequel of bacterial infection leading to pulmonary thromboembolism ?

A

Bacteria in the circulation (eg originating from ruminal epithelium in the case of ruminal acidosis) -> hepatic abscessation -> vena cava thrombosis -> emboli travel to heart and lung causing valvular endocarditis and pulmonary thromboembolism

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37
Q

What are the main pathogenic mechanism leading to pulmonary edema?

A
  1. Increased hydrostatic pressure (cardiogenic edema)
  2. Increased vascular permeability (injury to blood air barrier)
  3. Obstruction to lymphatic drainage. Eg neoplasm of thoracic lymph nodes or vessels
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38
Q

What is pulmonary anthracosis?

A

Carbon deposits int he lungs usually around brochioles

Pinpoint black discoloration
Usually linked with exposure to pollution

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39
Q

___________ is an incomplete expansion of lungs (or portions)

A

Atelectasis

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40
Q

Pulmonary parachyma is dark-red and sunken. Consistency is fleshy and dense.

A

Atelectasis

Can be acquired (space occupying lesions) or congenital

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41
Q

What are acquired causes of atelectasis ?

A
Space occupying lesions 
-hydrothorax
-hemothorax 
-pleutitis 
Pneumothorax 

Obstructive - inflammation or edema

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42
Q

What is meconium aspiration syndrome

A

Dystocia -> dedication in the amniotic sac -> inhalation -> patchy atelectasis and development of pulmonary disease

43
Q

___________ is permanent enlargement of airspaces distal to the terminal bronchioles, accompanied by destruction of alveolar walls

A

Pulmonary emphysema

-> decrease SA and gas exchange -> respiratory distress

44
Q

Pulmonary emphysema is always secondary to ____________________

A

Obstruction of outflow of air or agonal at slaughter

Freq in animals with bronchopneumonia

45
Q

What are the two types of emphysema in cattle?

A

Bulbous emphysema: large focal air-filled spaces (bulla) –>rupture causes fatal pneumothorax

Interstitial emphysema

46
Q

____________________ is characterized by discoloration (dark red) in the anteroventral portion of the lung

A

Supperative bronchopneumonia

Bacteria from an aerogenous route

47
Q

_________________ is characterized by a discoloured (red with yellow) in the anteroventral portion of the lung

A

Fibrinous bronchopneumonia

Yellow=> fibrous
Eg shipping pneumonia

48
Q

__________________ is characterized by lungs that have and increase in size, may have rib indentations, and have increased consistency

A

Interstitial pneumonia

-viral

49
Q

______________ is characterized by a multifocal dark red discolourations randomly distributed throughout the lungs

A

Embolic pneumonia

-systemic bacterial infections

50
Q

____________________ is characterized by a multifocal yellowish/white discolourations randomly distributed throughout the lungs

A

Granulomatous pneumonia
-> Fungal/mycobacterium

Tumor metastases (a larger lesion will demonstrate that the primary tumor originated in the lungs)

51
Q

______________ is characterized by a multifocal dark-red with yellow, discolourations that is distributed through the middle and caudal lobes the lungs

A

Porcine fibrinous pleuropneumonia

Actinobacillosis

52
Q

______________ is characterized by bronchitis and pneumonia in the distal end of the caudal lung lobes

A

Verminous pneumonia (lung worms)

53
Q

________________ is characterized by a unilateral discolouration in the anteriocaudal lung

A

Aspiration pneumonia

54
Q

_______________ is characterized by unilateral discolouraton in an animal who has had prolonged recumbency

A

Hypostatic congestion

55
Q

What are the viral pneumonias of cattle?

A

Infectious bovine rhinotracheitis
Para-influenza 3 virus
Bovine respiratory syncytial virus

56
Q

Formation of syncytial cells occurs in _________ and ___________ infections

A

Bovine respiratory syncytial virus (BRSV)

Para-influenza 3 virus

57
Q

What is the etiology of bovine enzootic pneumonia?

A

Mycoplasma
Chlamydiophila

Pasteurella 
Trueperella 
Histophilus 
Mannheimia 
E.coli
58
Q

What deficiency in calves prevents the migration of neutrophils forms he capillaries, making them highly susceptible to bronchopneumonia?

A

Bovine leukocyte adhesion deficiency (BALD)

59
Q

What acute respiratory disease can occur in cattle after shipment ?

A

Shipping fever

Mannheimia heamolytica -> most economically important respiratory disease of cattle in N. America

60
Q

What distribution will shipping fever have in the lungs?

A

Anteroventral

Fibrous bronchopneumonia

61
Q

Lung is bright red with interstial areas filled with fibrin, giving a marbled appearance. What is the MDx?

A

Fibrinous necrotizing supperative pneumonia

Pneumonic mannheimiosis

62
Q

What disease does histophilus somni cause and what lesions will it cause in the lungs?

A

Sleepers sickness

Supperative or fibrinous bronchopneumonia

63
Q

What bacteria is the most important cause of chronic respiratory disease in North American feedlot cattle?

A

Mycoplasma bovis

Chronic necrotizing bronchopneumonia

64
Q

What type of necrosis is seen in bronchopneumonia caused by mycoplasma bovis

A

Caseous necrosis

- loss of architecture, surrounded by a rim of inflammatory cells

65
Q

Granulomatous pneumonia in cattle. What should you suspect as a primary etiology?

A

Mycobacterium bovis

Will also see lesions in retropharyngeal l.n., lungs, thoracic and mesenteric l.n.

66
Q

What are the lungworms found in cattle, sheep, and equids?

A

Dictylocaulus viviparus - cattle
Dictylocaulus filaria - sheep and goat
Dictylocaulus arnfeldi- equids

67
Q

Cattle

Interstitial pneumonia and broncititis, located in the caudal lung lobes. You also see catarrhal discharge

A

Caudal lung lobes-> parasitic

Lung worms of cattle==> dictylocaulus viviparus

68
Q

Pig
You see numerous thin and elongated worms within the terminal bronchi of the caudal lung lobes. What is your MDx? Etiology?

A

Verminous bronchitis/pneumonia

Metastrongylus spp

69
Q

Cow with…. Edema, interstitial emphysema, hyaline membranes, type II pneumocytes hyperplasia and interstitial fibrosis

A

atypical interstitial pneumonia

70
Q

What are common syndromes causing atypical interstitial pneumonia?

A

Bovine pulmonary edema and emphysema (fog fever)

Extrinsic allergic alveolitis

Reinfection syndrome (dictylocaulus sp or BRSV)

Milk allergy

Ingestion of moldy potatoes -> 4-ipomeanol is metabolized by mixed function oxydases in the lung (Clara cells)

71
Q

What is fog fever?

A

Boveine pulmonary edema and emphysema

Cattle grazing on ‘fog’ pastures (re-growth pasture after a hay or silage has been cut or lush green)

L-tryptophan is present and metabolized to 3methylindole ->absorbed into the blood and carried to lungs ->

Clara cells and mixed function oxidase metabolize to pneumotoxic compound –> necrosis of bronchioles epithelial cells and type I pneumocytes (diffuse aveolar damage)

72
Q

Extrinsic allergic alveolitis is most commonly seen in adult diary cows during what season?

A

Winter

73
Q

What is extrinsic allergic alveolitis?

A

Type III hypersensitivity rxn to inhaled organic antigens, most commonly fungal spores in moldy hay –> deposit of Ag-Ab complex in lungs

74
Q

What viruses cause pneumonia in sheep?

A

PI-3
RSV
Maedi-visna

75
Q

Maedi is also known as ____________________, and occurs where in the world?

A

Ovine progressive pneumonia (OPP)

Australia and New Zealand

76
Q

What virus of sheep results n lymphocytic interstitial pneumonia and may also cause a nonpsupperative encephalitis, lymphocytic arthritis, and lymphofollicular mastitis and vasculitis?

A

Maedi (maedi-visna)

Ovine lenivirus

77
Q

What bacteria are involved in chronic enzootic pneumonia in sheep?

A

Mannheimia hemolytica
Pasteurella multocida
Chlamydophila
Mycoplasma ovipenumoniaee

78
Q

A septicemic pasteurellosis causing necrotizing pharyngitis and tonsillitis, septicemia with disseminated intravasular thrombosis and bacteremia, is usually caused by ______________ in lambs under three months and by _____________ in lambs 5-12months

A

Mannheimia hemolytica; Biberstenia trehalosi

79
Q

What is the etiologic agent causing verminous bronchitis in sheep and goats?

A
Dictylocaulus filaria 
Muellerius capillaries (sheep only)
80
Q

What viruses are important causes of pneumonia in horses?

A

Equine viral rhinopneumonitis (EHV-1 and EHV-4)
Equine influenza
Equine viral arteritis
Equine adenovirus

81
Q

Viral respiratory infections in horses can predispose them to what disease?

A

Airway hyper-responsiveness

Recurrent airway obstruction

82
Q

Interstitial pneumonia due to ____________ or _________ infection are a common complication in Arabian foals with SCID

A

Adenovirus; pneumocystis carinii

83
Q

What bacterial organism is an important cause of chronic pyogranulomatous pneumonia in foals worldwide

A

Rhodococcus equi

-> virulence factors encoded on plasmids

84
Q

What is responsible for the extensive caseous necrosis of the lungs seen in infections with Rhodococcus equi?

A

Cytokines, lysosomal enzymes and bacterial toxins

–> recruitment of neutrophils, macrophages, and giant cells

85
Q

T/F: Rhodococcus equi is a potential zoonotic microorganism and can infect immunocompromised people

A

True

86
Q

What are the viral pneumonias of pigs?

A

Porcine reproductive and respiratory syndrome

Swine influenza

Postweaning multi systemic wasting syndrome (porcine circovirus 2)

Porcine respiratory coronavirus

87
Q

What bacteria of pigs induces supperative or catarrhal bronchopneumonia with BALT hyperplasia

A

Mycoplasma hyopneumoniae

88
Q

PM of pig

Abnormal amounts of fibrin in thoracic and abdominal cavity.
This is characteristic of what disease?

A

Glassers disease

Hemophilus parasuis

89
Q

PM of pig

hemorrhagic necrosis that is locally extensive across the the dorsal area of the caudal lobes of the lungs

This is pathoneumonic for what disease?

A

Actinobacillus pleuropneumoniae

On a cut surface of the lung, will appear marbeled

90
Q

What are the two most common infectious pneumonias of dogs?

A

Infectious tracheobronchitis (kennel cough)

Canine distemper

Also canine adenovirus type 2, canine herpesvirus 1, and canine influenza

91
Q

Non infectious pneumonias of dogs are caused by?

A

Toxity

Uremia and Paraquat (herbicide)

92
Q

PM on a dog..

Necrotic tissue localized to the crainial lung lobes of the left side of the lung

What is the most likely cause?

A

Aspiration pneumonia

Can see other focal areas of necrosis in the pulmonary tissue

93
Q

Dog with widely spread mineralization in the alveolar septate

A

Uremic pneumonia

94
Q

T/F: pneumonias are common in cats?

A

False

Upper respiratory infections are common in cats

95
Q

What lung worm can be found in cats?

A

Aelurostrongylus abstrusus

Snail and slug IH
Nodules in lungs will contain larvae and eggs

96
Q

A common tumor in cats and dogs, lungs have multifocal areas of blood filled cysts.

A

Hemangiosarcoma

97
Q

PM in dog

Multifocal areas of black pigmentation on the surface of the lung

Dx?

A

Melanoma

98
Q

Dog with

Pale-tan areas of regeneration in the lungs
Hydrothorax
Lungs have multifocal areas of atelectasis

Dx

A

Severe chronic hepatitis

Fatty change in liver -> generalized edema -> hydrothorax -> atelectasis due to pressure of fluid on lungs

99
Q

Milky white fluid in the thoracic cavity of a dog?

A

Chylothroax

100
Q

Fibrinous pleuritis in a horse is due to???

A

Streptococcus equi subsp zooepidemicus

Shipping fever

101
Q

Pasteurella multocida infection in a cat can lead to ___________

A

Pyothorax

102
Q

Chronic pleutitis with sulfur granules is associated with what bacteria?

A

Nocardia

103
Q

______________________ seen mainly in cattle can be congenital and is associated with inhalation of asbestos

A

Mesothelioma