Hematopoietic 2

Question 1

Diffuse enlargement of the spleen is due to what three main causes?

Answer 1

Congestion
Cell proliferation/infiltrator
Accumulation of extracellular material

Question 2

Splenomegaly that appears in nodules is due to?

Answer 2

Neoplasia

Non-neoplastic like...
Hematoma
Infarct 
Modular hyperplasia 
Follicles lymphoid 
Fibrohistiocytic nodules 
Sicertoic plaques

Question 3

Spleen that is uniformly enlarged with a bloody consistency is due to ??

Answer 3

“Bloody spleen”
Congestion
Acute hyperemia
Acute hemolytic anemia

Question 4

A uniformly enlarged spleen with a firm consistency is due to?

Answer 4

“Meaty spleen”
Increased infiltration of cells

• phagocytosis
• proliferation of cells
• storage of material

Question 5

Splenic nodules with a bloody consistency can be due to???

Answer 5

Hematoma
Incomplete contraction of area of spleen
Acute splenic infarct
Vascular neoplasia

Question 6

Splenic nodules with a firm consistency can be due to?

Answer 6

Splenic nodular hyperplasia 
Fibrohistiocytic nodules 
Primary neoplasm 
Secondary neoplasm 
Granuloma 
Abscess

Question 7

A small spleen can have what causes?

Answer 7

Developmental abnormality 
Aging changes
Wasting/cachexia 
Splenic contraction 
Ionizing radiation 
Splenic trauma

Question 8

What are the degenerative lesions of the spleen?

Answer 8

Siderfibroiris
Hemosiderosis
Amyloidosis

Question 9

Gray - white- yellow, hard, dry encrustations on capsule of spleen along the margins

Answer 9

Siderotic plaques

Question 10

How does hemosiderosis occurs?

Answer 10

Decreased rate of erythropoiesis (less iron demand), or or destruction f RBC –> macrophages take up iron

Question 11

What is amyloid?

Answer 11

Abnormally folded proteins –> Bsheets that accumulate outside of the cell