PNS Flashcards
What is a good way to preserve myelin sheath in a fixed preparation of a nerve?
Plastic embedded
What is coonhound paralysis?
Acute ascending paralysis in dog after a scratch or bite wound from a raccoon
-autoimmune disease causing demyelination and influx of inflammatory cells
Dog with hyperesthesia, weakness, ataxia, leading to tetraparesis that can last for weeks or months
Coonhound paralysis
What do you call a disease that has demyelination of nerve roots in dogs/cats that have no history of contact with raccoons ?
Acute idiopathic polyradiculoneuritis
What is Guillan-Barre syndrome?
Splitting of myelin lamellae
Accumulation of debris
Demyelination
What is neuritis of the cauda equina?
Chronic inflammation of the extramural portions of the nerve roots of the cauda equina
–> tail and sphincter paralysis
What disease are these lesions associated with?
Thickened nerve root due to infiltration of inflammatory cells
Demyelination and axonal degeneration
Neuritis of the cauda equina
What is the etiology of neuritis of the cauda equina?
Probably immune mediated
What kind of infiltrate is seen in cauda equina neuritis?
Lymphocytic
Avulsion of the brachial plexus is usually due to?
Trauma
What is the pathogenesis of amputation neuromas?
Abortive attempts of regeneration of severed axons
Result in severe pain
Eg tail dock neuroma
You go to your barn where your cow is giving birth, the legs are splayed
Calving paralysis
bilateral compressive damage of the obturator nerve -> no innervation of the adductor muscles
What are metabolic and nutritional disorders of the PNS?
Lysosomal storage diseases
Diabetic neuropathy
Hypothyroid neuropathy
Cat,
super duper fat
Plantigrade stance in the hindlimb.
Amyloid deposition in pancreatic islets
Leads to axonal degeneration and vasculopathy
Associated with diabetes
What type of toxins can result in peripheral neuropathic
Lead
Thallium
Mercury
