Resp. Histopathology Flashcards
which life stage is this parasite in
embryonated eggs
what life stage is this parasite in
larvae
what life stage is the parasite in
adult
The adult worms are in the lumen of what pulmonary structure?
Select one:
a. Pleura
b. Bronchiole
c. Trachea
d. Alveoli
e. Bronchus
bronchiole
The black arrow is pointing at the lining of the structures referenced above. What kind of cells are these?
Select one:
a. Ciliated epithelial cells
b. Macrophages
c. Squamous epithelial cells
d. Clara cells
ciliated epithelial cells
There is a blue arrow pointing at a cluster of inflammatory cells. Can you identify what type of cells they are? (Hint: they have pink cytoplasmic granules and lobular nucleus.)
Select one:
a. Macrophages
b. Neutrophils
c. Lymphocytes
d. Eosinophils
e. Plasma cells
eosinophils
The majority of inflammatory cells in this region, however, are macrophages (yellow arrow) that are mostly arranged in loose sheets. There are very rare multinucleated giant cells (MNGC) scattered throughout – bonus points if you can spot any!
What type of inflammation is characterized by sheets of macrophages, and often has MNGC as well?
Select one:
a. Catarrhal
b. Granulomatous
c. Lymphoplasmacytic
d. Suppurative
e. Pyogranulomatous
granulomatous
What descriptive term would you use to describe the distribution of the parasite-associated lesions in this slide?
Select one:
a. diffuse
b. multifocal to coalescing
c. focal
multifocal to coalescing
This is an example of Muellarius capillaris. What is the typical gross distribution of associated lesions?
Select one:
a. Caudodoral distribution in a subpleural location
b. Scattered throughout all lung lobes
c. Cranioventral consolidation
d. Located throughout the parenchyma
Caudodoral distribution in a subpleural location
The other nematode that is likely to be seen in lungs tissue of small ruminants would be Dictyocaulus filaria. The adults are significantly larger and would have a greater diameter as seen in cross-section. And grossly, the lesions are typically limited to the caudal periphery of the lung
Now, moving over to the piece of tissue on the right hand side of the slide…
You’ll see several nodular lesions circled in black. Go look more closely at these, and hopefully you’ll see that they are all quite similar to one another. Can you find a similar nodule in the section of lung on the left?
Select one:
a. Yes
b. No
There is a similar nodular lesion near the top of the left section of tissue.
Yes
The nodules are quite cellular. Do they look like mostly inflammatory cells?
Select one:
a. Yes
b. NO
You’ll likely find a few inflammatory cells mixed in, but the overwhelming population is not composed of inflammatory cells.
NO
The black circles are indicating areas of neoplasia. What is a general characteristic feature that helps identify a neoplastic proliferation?
Select one:
a. Mitoses
b. A proliferation of cells that makes a mass effect
c. Proliferation of a monomorphic (single type) of cell
Neoplasia is composed of a clonal population. All the cells should be of the same type.
Proliferation of a monomorphic (single type) of cell
What class of neoplasia do you think these nodules represent?
Select one:
a. Epithelial cell
b. Round cell
c. Mesenchymal cell
epithelial cell
In any species, these multifocal to coalescing nodules are consistent with a pulmonary carcinoma or pulmonary adenocarcinoma (“adeno” just indicates that there is a glandular/secretory function of the neoplastic cells). In sheep, Jaagsiekte disease, or Ovine Pulmonary Adenocarcinoma, is a well-recognized syndrome with a very typical histologic appearance as seen on this slide.
How is OPA different from most other types of malignant neoplasia?
Select one:
a. OPA is NOT a progressive disease.
b. OPA is a virally induced neoplasm caused by JSRV
OPA is a virally induced neoplasm caused by JSRV
Which of the following images is representative of the gross lesions associated with Jaagsiekte?
Which of the following images is representative of the gross lesions associated with Jaagsiekte?
