Patterns of Disease in Lung: Neoplasia

Question 1

what is primary neoplasia

Answer 1

arise in the lung

most often epithelial in origin

Question 2

what is the name for a tumour of epithelial cells

Answer 2

papilloma, adenoma, carcinoma

Question 3

what are the features of primary lung tumours

Answer 3

typically have one “large” mass +/- intrapulmonary metastases

Question 4

what are secondary neoplasims

Answer 4

metastatic

arise elsewhere

lungs are common metastatic site due to massive blood flow and massive capillary bed

Question 5

what are the origins of primary lung tumours

Answer 5

typically epithelial origin –> adenoma or carcinoma

adenoma = benign

carcinoma (adenocarcinoma) = malignant

Question 6

what are the majority of lung tumours

Answer 6

malignant (roughly 80%)

Question 7

what is common in primary lung tumours

Answer 7

intrapulmonary metastases

Question 8

where can primary lung tumours metastasize to

Answer 8

may also metastasize to local lymph nodes, brain, bone

Question 9

what is feline “lung-digit” syndrome

Answer 9

pulmonary carcinomas (bronchial and bronchoalveolar carcinomas) have a tendancy to metastasize to multiple digits on multiple limbs

typically the first clinical sign in these cases

Question 10

what is shown here

Answer 10

neoplastic proliferation within caudal lung lobe

umbilicated appearance –> typical of carcinoma on gross appearance

Question 11

what is the cause of primary lung tumours in sheep

Answer 11

Jaagsiekte sheep retrovirus

ovine pulmonary adenocarcinoma OPA

Question 12

how does Jaagsiekte sheep retrovirus (JSRV) cause ovine pulmonary adenocarcinoma (OPA)

Answer 12

virus transforms alveolar epithelial cells (type II pneumocytes and clara cells) into neoplastic population

neoplastic cells produce abundant fluid

Question 13

what is the cause of this pathology

Answer 13

jaagsiekte

Question 14

what is the lesion here

Answer 14

jaagsiekte

lesions start in middle of the lung typically (middle lobe, cranial part of caudal lobe or caudal part of cranial lobe ) –> greyish, firm, poorly demarkated, exudate lots of fluid

trachea often filled with frothy fluid

Question 15

what is the histological changes of jaagsiekte lesions

Answer 15

proliferation of a single type of cell –> cuboidal to low columnar

arranged in a single cell thick, orderly layer that follows the pre-exisiting alveolar septa architechture

alveolar lined by neoplastic cuboidal cells

Question 16

what is occuring here

Answer 16

a mass was detected on the spleen

multi-focal coalescing opacities

metastatic pulmonary lesions

Question 17

is this a primary or metastatic lung tumour

dog has a history of hemoabdomen

Answer 17

multi-focal variably sized dark red nodules

metastatic hemangiosarcoma lung tumour –> because of the dark colour

Question 18

is this primary or metastatic

Answer 18

metastatic hemangiosarcoma

multifocal

histologically: neoplastic endothelial cells that are lining blood filled cavities

Question 19

is this a primary or metastatic lung tumour

Answer 19

metastatic lung tumour

multifocal distribution in cranial and caudal lobes

pale/white lesions

thyroid carcionma with pulmonary metastases

Question 20

what type of tumour is this

Answer 20

metastatic

multicentric lymphoma

Question 21

what distribution is this

Answer 21

primary lung tumour with secondary metastses

Question 22

what is this distribution

Answer 22

tumour metastases from a non-pulmonary primary site (mammary carcinoma)

Question 23

certain pulmonary carcinomas in cats metastasize to what location

Answer 23

multiple digits on multiple limbs

lung-digit syndrome