Renal Cell Carcinoma (Renal CA)

Question 1

renal cell carcinoma

Answer 1

• occurs in adults (after 50, avg is 60; males 2:1)
• 80-90% of kidney tumors
• arises in any part of kidney, most common place at poles

Question 2

risk factors (unclear cause)

Answer 2

• heavy smoking
• obesity
• HTN
• acquired cystic kidney disease assoc w/ chronic renal insufficiency

Question 3

5 variants

Answer 3

1) clear cell carcinoma (70-80%)

2) papillary tumors
3) chromophobic tumors
4) onocytomas
5) collecting duct tumors

Question 4

clear cell carcinoma variant

Answer 4

• clear cell cytoplasm
• Chr 3 deletion
• arises from proximal tubular epith cells

Question 5

mnfts

Answer 5

• absence of early mnfts

- classic triad

Question 6

classic triad mnfts

Answer 6

1) hematuria
2) flank pain
3) flank mass

Question 7

dx

Answer 7

• hematuria & renal mass present
• ultrasonography & CT scan
• MRI

Question 8

when is MRI done

Answer 8

when involvement of inferior vena cava suspected

Question 9

Tx

Answer 9

• Sx (nephrectomy w/ lymph node removal)
• single-agent & combo chemo (limited success)
• immunotherapy

Question 10

5-yr survival rate

Answer 10

• 90% of tumor within kidney

- 20% if mets occurred