Inflammatory Bowel Disease (IBD) Flashcards
1
Q
inflammatory bowel disease
A
- inflm of large and small intestine
- chronic and progressive disease
2
Q
2 chronic diseases
A
- Crohn’s disease
- Ulcerative Colitis
3
Q
etiology
A
- genetic susceptibility
- lose self-tolerance for normal gut flora d/t affected HLA/MHC genes; immune system targets bacteria attached to gut wall –> inflm
- environmental triggers (d/t complex trait etiology)
4
Q
Crohn’s disease type of lesions and affected area
A
- granulomatous, inflammatory skip (non-continuous) lesions seen in small and large intestine
- primarily affects submucosa of terminal ileum
- slowly progressive, non-aggressive disease
5
Q
submucosa
A
2nd layer of dense irreg CT
6
Q
terminal ileum
A
end of small intestine
7
Q
mnfts of Crohn’s disease
A
- intermittent diarrhea
- colicky pain (spasmodic) in abd
- weight loss
- fluid & electrolyte imbal d/a diarrhea
8
Q
why is weight loss mnft of Crohn’s disease
A
- Crohn’s disease mainly affects the terminal ileum
- ileum’s major Fx is absorption
- damage to intestinal wall impairs absorption Fx (nutrients not absorbed as effectively)
- also d/t diarrhea
9
Q
cmplx of Crohn’s disease
A
- fistulas
- abscesses
- bowel obstruction
- stricture
10
Q
fistulas
A
refers to an abn passage b/w hollow of tubular organ and body surface or b/w 2 hollow or tubular organs
11
Q
abscesses
A
swollen area of body containing accumulation of pus (perianal area)
12
Q
stricture
A
constriction of tube (aka intestine, may result in obstruction)
13
Q
Ulcerative Colitis lesion and affected area
A
- continuous ulcerative lesions (ulcers)
- at terminal part of large intestine
- primarily affects mucosa of colon & rectum (inner lining of lumen)
14
Q
continuous lesions
A
- crypt abscesses
- bleeding ulcers
- thickened and inflamed tissue
- pseudopolyps
15
Q
crypt abscesses
A
- crypts normally secrete digestive Es and regenerate new tissue when damaged
- accum of pus in crypts prevents regrowth of new tissue (leads to colorectal CA)
