Cholelithiasis

Question 1

cholelithiasis

Answer 1

precipitation of bile content –> gall stones

Question 2

etiology

Answer 2

• genetic predisposition
• altered bile composition (abn bile components)
• bile stasis

Question 3

how does an altered bile composition cause cholelithiasis

Answer 3

inc precipitate in bile –> stones to form

ex. high cholesterol in bile precipitates

Question 4

how does bile stasis cause cholelithiasis

Answer 4

obstruction in the bile pathway (ex. constricted ducts) –> bile precipitates –> stones form

Question 5

patho

Answer 5

nucleus forms from inflammatory debris, cellular components –> precipitation goes around the nucleus –> stones develop

Question 6

stone types

Answer 6

• cholesterol stones
• pigment stones
• mixed stones

Question 7

cholesterol stones composition

Answer 7

bile and excess cholesterol

Question 8

pigment stones composition

Answer 8

bilirubin and Ca2+ salts

Question 9

mixed stones composition

Answer 9

cholesterol, bilirubin, phosphate, Ca2+

Question 10

mnfts

Answer 10

• asympt until stone migrates into bile duct

- if stone migrates into bile duct, it causes: pain + N/V

Question 11

what pain occurs

Answer 11

intermittent colicky pain that radiates from flank to groin and chest

Question 12

why is the pain intermittent

Answer 12

d/t stone’s migration path

Question 13

dx

Answer 13

• Hx, Px
• U/S
• CT scan

Question 14

tx

Answer 14

• pain meds
• dissolving agents to break up stone
• Sx to remove stones