Regulation of Immune Response

Question 1

Which cytokines do TH-2 release?

Answer 1

IL-4, IL-5, IL-10, IL-13

Question 2

Cytokines released by T-reg?

Answer 2

IL-10 and IL-35

Question 3

Il-10, TNF and IFN alpha and gamma are released by these T cells

Answer 3

Tcytotoxic

Question 4

NKT cells release these cytokines

Answer 4

IL-2, IL-4, IFN-gamma, TNF

Question 5

Describe the function of CCR7

Answer 5

Directs DC to lymph nodes and spleen.

Question 6

Which factors lead to anergy

Answer 6

low (MHC, B7, CD40, CCR7)
IL-10
TGF-beta

Question 7

B cell tolerance mechanisms include these possible outcomes

Answer 7

apoptosis
receptor editing/recombination
anergy

Question 8

Ways T-regs regulate T cells

Answer 8

1. block cytokines and push into cell cycle arrest
2. Consume IL-2 and lead to apoptosis
3. release granzymes and cause apoptosis
4. Attach to DC and release kynurei which cause cell cycle arrest

Question 9

What is IPEX?

Answer 9

immune disregulation poly endocrinopathy/enteropathy x-linked syndrome

Question 10

Labs results seen in IPEX?

Answer 10

increased eosinophils and IgE

Question 11

mutation in this gene causes IPEX

Answer 11

tf - FOX3P

Question 12

lack of these cells in IPEX cause these systemic problems

Answer 12

no Treg

autoimmune inflammation

Question 13

Describe some physical manifestations of IPEX

Answer 13

watery diarrhea, FTT and dermatitis

Question 14

Treatment of IPEX

Answer 14

immunosuppresion (cyclosporin, tacrilumis)

BMT