Complement

Question 1

List functions of complement

Answer 1

lysis
opsonization
mediated the inflammatory response
clear immune complexes and dead cells
augments stimulation of B cells

Question 2

complement is best suited for these things

Answer 2

fighting infection and removing immune complexes

Question 3

Name one immuncomplex disease, and the missing components

Answer 3

SLE, C1,2,4,3 - Classical or Lectin Pathway

Question 4

This organism is only cleared by complement

Answer 4

Meningococcal infection

Question 5

Bacteria are mostly killed by these pathways

Answer 5

Lectin and Alternative

Question 6

Location of complement

Answer 6

plasma, interstitial and in secretions

Question 7

Most common complement

Answer 7

C3

Question 8

3 Activators of Complement

Answer 8

Classical - antigen antibody
Polysaccharides/mannose - Lectin
LPS, Foreign substance, Nucleophiles - Alternative

Question 9

Proteolycic cleavages happen for these steps of complement

Answer 9

Thru C5

Question 10

denoted by letter a, letter b, and exception

Answer 10

smaller, larger, C2

Question 11

attachment of C4b and C3b is via these bonds

Answer 11

covalent thioester bonds

Question 12

Binding of C1q to antibody causes this

Answer 12

Conformation change of C1q and cleavage of C4

Question 13

bacteria that start MBL pathways

Answer 13

Salmonella, listeria, neiserria candida

Question 14

Factor B and D are a part of this pathway

Answer 14

Alternative

Question 15

Acid we have that makes complement less likely to bind

Answer 15

Sialic acid

Question 16

Purpose of properdin

Answer 16

stabilize the alternative pathway C3 convertase(C3bB3)

Question 17

Why don’t we lyse our own cells

Answer 17

no ab to ourselves
enzymes short t 1//2
non-activator surfaces
inhibitors - fluid phase and membrane

Question 18

If you have no factor H get this

Answer 18

Hemolytic syndrome

Question 19

A deficiency of C1INH causes this disorder of the Classical pathway

Answer 19

Hereditary angioedema

Question 20

Hereditary angiodema cause overactive complement. What components are overly produced?

Answer 20

C2 and C4

Question 21

Anabolic steroids, replacement proteins and kinin inhibitors are used to treat this.

Answer 21

Hereditary angiodema.

Question 22

A deficiency of these decay accelerating factors results in increased membrane attack complex and complement mediated hemolysis. Treament options?

Answer 22

CD55 and CD59 (protectin)

C5 antibody - ECULIZUMAB

Question 23

Name the protein that prevents binding of C8,C9 preventing formation of MAC

Answer 23

Protein S (Vitronectin)

Question 24

Excessive levels of these 2 anaphlatoxins can cause anaphlaxis and other inflammatory disease

Answer 24

C3a and C5a

Question 25

Which 2 Complement Receptors (CR) are involved in immune complexes

Answer 25

CR1 and CR3