Complement Flashcards
List functions of complement
lysis opsonization mediated the inflammatory response clear immune complexes and dead cells augments stimulation of B cells
complement is best suited for these things
fighting infection and removing immune complexes
Name one immuncomplex disease, and the missing components
SLE, C1,2,4,3 - Classical or Lectin Pathway
This organism is only cleared by complement
Meningococcal infection
Bacteria are mostly killed by these pathways
Lectin and Alternative
Location of complement
plasma, interstitial and in secretions
Most common complement
C3
3 Activators of Complement
Classical - antigen antibody
Polysaccharides/mannose - Lectin
LPS, Foreign substance, Nucleophiles - Alternative
Proteolycic cleavages happen for these steps of complement
Thru C5
denoted by letter a, letter b, and exception
smaller, larger, C2
attachment of C4b and C3b is via these bonds
covalent thioester bonds
Binding of C1q to antibody causes this
Conformation change of C1q and cleavage of C4
bacteria that start MBL pathways
Salmonella, listeria, neiserria candida
Factor B and D are a part of this pathway
Alternative
Acid we have that makes complement less likely to bind
Sialic acid
Purpose of properdin
stabilize the alternative pathway C3 convertase(C3bB3)
Why don’t we lyse our own cells
no ab to ourselves
enzymes short t 1//2
non-activator surfaces
inhibitors - fluid phase and membrane
If you have no factor H get this
Hemolytic syndrome
A deficiency of C1INH causes this disorder of the Classical pathway
Hereditary angioedema
Hereditary angiodema cause overactive complement. What components are overly produced?
C2 and C4
Anabolic steroids, replacement proteins and kinin inhibitors are used to treat this.
Hereditary angiodema.
A deficiency of these decay accelerating factors results in increased membrane attack complex and complement mediated hemolysis. Treament options?
CD55 and CD59 (protectin)
C5 antibody - ECULIZUMAB
Name the protein that prevents binding of C8,C9 preventing formation of MAC
Protein S (Vitronectin)
Excessive levels of these 2 anaphlatoxins can cause anaphlaxis and other inflammatory disease
C3a and C5a
Which 2 Complement Receptors (CR) are involved in immune complexes
CR1 and CR3
