Immunosuppressive Drugs Flashcards
1
Q
What classes of drugs are used to prevent organ transplantation rejection?
A
Calcineurin inhibitors
anti-proliferative/anti-metabolic drugs
antibodies
2
Q
What enzyme is inhibited by Mycophenolat mofetil?
A
IMPDH
3
Q
Which immunosuppressive drug works by binding gp of TCR and prevention of antigen recognition?
A
Muromonab
4
Q
Describe Daclizumab/Basiliximab MOA
A
They are anti-IL-2 receptor (antiCD25) and block IL-2 mediated responses
5
Q
Describe the 2 ways cyclosporin and tacrolimus inhibit Calcineurin activity
A
cyclosporin binds cyclophilin
tacrolimus binds FKBP
