Anti Coag Drugs Flashcards

1
Q

Name the 8 antiplatelet drugs we learned

A
Aspirin
Clopidogrel
Ticlopidine
Prasugrel
Dipyridamole
Abcixamab
Eptifibabtide
Tirofiban
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2
Q

Which drugs are ADP receptor antagonist

A

Clopidogrel, Ticlopidine, Prasugrel

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3
Q

Abciximab, Eptifibatide, and Tirofiban all work via this mechanism

A

GPIIb/IIIa receptor inhibitor

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4
Q

Heparin potentiates this

A

Antithrombin III to inactivate Xa and IIA leads to no clotting

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5
Q

Direct Thrombins work via this mechanism

A

bind to thrombin and inhibit enzyme

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6
Q

Antidote for heparin?

A

Protamine - binds to neg. charged heparin and prevents its action

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7
Q

Describe the 3 types of indirect thrombin anti-coagualtion drugs

A

Unfractionated heparin - inactivate Xa and IIa
Low molecular weight heparin - inactivate Xa and some IIa
Fondaparinux - inactivate Xa - not reversed by protamine

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8
Q

Most common oral anticoagulation drug

A

Warfarin

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9
Q

Purpose of tPA drugs

A

activate plasminogen and dissolves thrombi

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10
Q

name the 4 direct thrombin drugs

A

Lepirudin
Bivalirudin
Argatroban
Dabigatran etexilate

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11
Q

How does Warfarin work?

A

Blocks synthesis of vitamin K dependent clotting factors

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12
Q

Antidote for warfarin?

A

Vitamin K (Phytonadione)

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13
Q

Describe the process of plasminogen and clot breakdown

A

plasminogen —> plasmin, plasmin breaks clot down to FDP

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14
Q

Describe a pharmacodynamic effect between warfarin and the body

A

effect of drug on body
decrease platelet/clotting factors
decrease availability of vit. K

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15
Q

ADME describes the effects of the body on drugs also called this?

A

Pharmacokinetics

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16
Q

Warfarin works between these 2 proteins

A

precursors of prothrombin to prothrombin

17
Q

2 drugs that have drug-drug interactions

A

Warfarin - multiple - CYPT 450

Clopodogrel - Cyp2A19 activation