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IHO Final > Hematopietic Viruses > Flashcards

Hematopietic Viruses Flashcards

1
Q

Name 2 naked viruses

A

Parvovirus and Colorado Tick Fever

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2
Q

Pathology of HHV6/7

A

Roseola - kids, encephalitis/mono - adults

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3
Q

Name hemat ds DNA viruses

A

CMV
HHV-6/7
HHV-8 (circular)

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4
Q

Virus with ssRNA (+) genome

A

HTLV-1 and 2

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5
Q

Virus with ssDNA

A

Parvovirus

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6
Q

Pathology of HTLV-1 and 2

A

Acute T cell Lymphoma (ATL)

HTLV Assocaited Mylopathy (HAM)

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7
Q

Treatment for severe CMV?

A

Ganciclovir

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8
Q

Mechanism of action for Foscarnet?

A

Pyrophosphate analog which is noncompetitive inhibitor of viral DNA pol and HIV transcriptase

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9
Q

Symptoms of Colorado tick fever

A

biphasic fever, chills, ha, myalgia, leukopenia

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10
Q

Virulence factor for Colorado tiCk fever?

A

Evades Dicer-Risc via internal caspid coat.

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11
Q

Diagnostic test for Colorado Tick Fever?

A

ELISA or immunoflourescent (better)

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12
Q

Tropism for Parvovirus

A

Erythroid progenitor cells

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13
Q

Name the homologous proteins that HHV-8 uses to promote viral growth

A

vFLIP, V-BCL2, v-cyclin and VEGFR

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14
Q

Symptoms of HTLV assoicated myopathy

A

paresis and demyleination

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15
Q

Treatement for HTLV1/2

A

Chemo and BMT

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16
Q

What virus cause deafness/blindness in congential cases?

A

CMV

17
Q

What virus causes exanthem subitum in children?

A

HHV6/7

18
Q

Diagnosis of Parvovirus looks for this?

A

B19 IgM

19
Q

HHV-8 infects what type of cells?

A

B cells

20
Q

T cells infected in HTLV 1 and 2?

A

CD4+ and CD8+

21
Q

Infection in anemic patient of Parvovirus can cause this

A

TAC

22
Q

Binding site and replication strategy for Parvorvirus?

A

P-antigen, NS1 protein insertion is cytotoxic

23
Q

What virus would show Owl Eye Cells in the blood smear?

A

CMV

24
Q

Virus with segmented ds RNA?

A

Colorado Tick Fever

IHO Final (40 decks)

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