Anti-inflammatory Drugs Flashcards
On a Bronchoconstriction versus log histamine graph- what effect would adding Loratadine have to the curve?
Right shift
On a Bronchoconstriction vs. log ACh graph what effect would adding Diphenhydramine have?
Right shift
On a bronchoconstriction vs log AcH graph what effect would adding Fexofenadine have?
None
Name the leukotriene modifiers
zileuton
zafirlukast
montelukast
What things are signifigant about indomethacin
very potern, cause frontal headaches, kidney and GI problems
Name the prescription NSAID medications
Ketorlac Indomethacin Sulindac Ketoprofen Piroxicam
What are some advantages of SGE Antihistmines?
Do not cause drowsiness, less secretion drying
What enzyme does zileuton block?
5-lipoxygenase
Side effect of piroxicam?
Serious GI bleed
Why don’t SGA antihistamines cause drowsiness?
Very little crosses the BBB and it has affinity for P-glycoprotein
What enzyme converts Histidine to histamine?
L-histine decarboxylase
What are the effects of histamine binding with a H1 receptor?
bronchoconstriction capillary permeability itching pain hypersensitivity
Binding to what Histamine receptor increases gastric acid secretion?
H2
Some effects seen with H1/H2 mixed receptors?
Cardiac
Vasodilator
Triple response
Nasal symptoms
Antihistamines are classsically considered this type of drug? In fact they are this type of drug.
Antagonist
inverse agonist
