Anti-inflammatory Drugs Flashcards
On a Bronchoconstriction versus log histamine graph- what effect would adding Loratadine have to the curve?
Right shift
On a Bronchoconstriction vs. log ACh graph what effect would adding Diphenhydramine have?
Right shift
On a bronchoconstriction vs log AcH graph what effect would adding Fexofenadine have?
None
Name the leukotriene modifiers
zileuton
zafirlukast
montelukast
What things are signifigant about indomethacin
very potern, cause frontal headaches, kidney and GI problems
Name the prescription NSAID medications
Ketorlac Indomethacin Sulindac Ketoprofen Piroxicam
What are some advantages of SGE Antihistmines?
Do not cause drowsiness, less secretion drying
What enzyme does zileuton block?
5-lipoxygenase
Side effect of piroxicam?
Serious GI bleed
Why don’t SGA antihistamines cause drowsiness?
Very little crosses the BBB and it has affinity for P-glycoprotein
What enzyme converts Histidine to histamine?
L-histine decarboxylase
What are the effects of histamine binding with a H1 receptor?
bronchoconstriction capillary permeability itching pain hypersensitivity
Binding to what Histamine receptor increases gastric acid secretion?
H2
Some effects seen with H1/H2 mixed receptors?
Cardiac
Vasodilator
Triple response
Nasal symptoms
Antihistamines are classsically considered this type of drug? In fact they are this type of drug.
Antagonist
inverse agonist
Things that contribute/make hives?
histamine
prostaglandins
leukotriene
Structural difference between Bradykinin and Kallidin
Bradykinin - 9 aa - ends with Lys
Kallidin - 10 aa - ends with Lys-Arg
Which prostaglandins cause bronchostriction?
PGd and TXA
Which prostaglandin cause many symptoms including vasodilation, increased vascular permeability, pain, redness, and fever?
PGe
What effects do peptido leukotrienes have on the body?
swelling, chemotaxis and bronchoconstriction
Bradykinins have numerous effects on the body. Name some of them
swelling, pain, bronchoconstiction, hypotension and redness
Name the first generation antihistamines
Diphenhydramine
Chlorpheniramine
Name 3 things that happen in acute inflammation
change in blood vessel caliber and flow
increased vascular permeability
leukocytic infiltration
Which anti-inflammatory therapy targets multiple mediators?
NSAID
anti-inflammatory steroids
What effect do bradykinins have on the cardiovascular system?
Decrease BP
