EBV

Question 1

Describe diagnostic test for Mono

Answer 1

Mono-spot
Looks for heterophile antibodies -
IgM - acute infection
IgG - past infection
None- inconclusive

Question 2

These cells on a blood smear are diagnostic for Mono

Answer 2

Downey cells and abnormal granulocytes

Question 3

Name 3 viral oncogenes for EBV

Answer 3

LMP-1, LMP-2, EBNA3C

Question 4

What cell signal does LMP-1 mimic which results in B-cell activation?

Answer 4

CD-40

Question 5

What EBV viral oncogene mimics a B-cell receptor and increases transcription of this pathway?

Answer 5

LMP-2

Map-K

Question 6

EBNA3C binds what complexes to increase DNA replication and progress the cell cycle

Answer 6

Cyclin - D and cdk

Question 7

List the triad of symptoms for EBV

Answer 7

Pharyngitis, Lymphadanopeathy, Fever

Question 8

List cancers that infection with EBV puts you at risk for later in life?

Answer 8

Hodgkins
Non-Hodgkins
Burkitts Lymphoma
Nasopharyngeal carcinoma
x-linked lymphroliferative disease.

Question 9

Genome for eBV

Answer 9

ds DNA

Question 10

In which cells does the lytic cell of EBV occur in? and where is it latent

Answer 10

lytic - epitheleal cells of nasopharynx

latent - B-cells

Question 11

This recessive x-linked disease is caused by a mutation in the SAP protein which decreases IL-4. In this disorder you have this problem with your immune system?

Answer 11

X-linked prolipheraitve disease

Immune response does not shut off

Question 12

List symptoms of x-linked prolipherative disease?

Answer 12

Acute infectious mono around the age of 3. Often fatal if survive will have lymphopoliferative disease and dysgammaglobinemia