(QUIZ) TB Flashcards
TB 1st line treatment
Rifampin Isoniazid Pyrazinamide Emthambutol (Rifapentine/rifabutin)
TB 2nd line treatment
Fluoroquinolones (Levofloxacin/Moxifloxacin) Aminoglycosides (streptomycin/amikacin) Cycloserine Ethionamide CAPreomycin PAS para-aminosalicylic acid
TB intensive phase drugs
Isoniazid
Rifampin
Pyrazinamide
Ethambutol
TB continuation phase drugs
Isoniazid
Rifampin
TB drugs used if resistant to rifampin OR isoniazid
Ethambutol and pyrazinamide + (rifampin/isoniazid)
Extensively drug resistant to resistant to
Isoniazid & rifampin
Fluoroquinolone
(levo & Moxifloxacin)
One 2nd line injectable (amikacin, capreomycin, streptomycin)
Multi-drug resistant treatment
5, 6, or 7 drugs Isoniazid Rifampin Pyrazinamide Ethambutol Amikacin Capreomycin Levofloxacin Cycloserine PAS
TB plus HIV treatment
Rifampin accelerates metabolism of protease inhibitors and NNRTI’s
Substitute for rifabutin
Latent TB treatment
Isoniazid , rifampin, or isoniazid + rifapentine
Isoniazid interactions
Inhibitor of CYP enzymes ^Phenytoin ^carbamazepine ^diazepam ^triazolam
Isoniazid AE
Peripheral neuropathy Hepatotoxicity Optic neuritis, seizures, dizzy, ataxia, psychological disturbances (Crosses BBB) Anemia
Rifampin interactions
Induces P450, ^drug metabolism
Warfarin
BC
HIV meds (NNRTI’s)
Rifampin AE
Hepatotoxic
Orange body fluids
GI
Pyrazinamide AE
Hepatotoxic Non-gouty pararthalgia Hyperuricemia GI Photosensitivity
Ethambutol AE
optic neuritis Hyperuricemia Dermatitis Peripheral neuropathy Renal damage Thrombocytopenia
Levofloxacin and Moxifloxacin
???
Capreomycin & amikacin (inj)
Nephrotoxic
8th CN damage-vHearing, tinnitus, vBalance
Para-aminosalicylic acid AE
GI
Hepatotoxic
Goiter
^sodium loading
Ethionamide AE
Metallic taste GI!!! Hepatotoxic Peripheral neuropathy CNS-convulsions/Mental disturbance Allergic Hypoglycemia
Cycloserine AE
CNS effects frequent/severe
Anx,dep,conf, hallucination, paranoia, hyperreflexia, seizure, psychotic episode
Hepatotoxicity, peripheral neuropathy, vFolate
Bedaquiline
HIV pt’s can take bc ___
^____
Doesnt accelerate metabolism
^QT
$36k
