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Pharmacology > (QUIZ) TB > Flashcards

(QUIZ) TB Flashcards

1
Q

TB 1st line treatment

A 
Rifampin
Isoniazid
Pyrazinamide
Emthambutol
(Rifapentine/rifabutin)
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2
Q

TB 2nd line treatment

A 
Fluoroquinolones (Levofloxacin/Moxifloxacin)
Aminoglycosides (streptomycin/amikacin)
Cycloserine
Ethionamide
CAPreomycin 
PAS para-aminosalicylic acid
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3
Q

TB intensive phase drugs

A

Isoniazid
Rifampin
Pyrazinamide
Ethambutol

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4
Q

TB continuation phase drugs

A

Isoniazid

Rifampin

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5
Q

TB drugs used if resistant to rifampin OR isoniazid

A

Ethambutol and pyrazinamide + (rifampin/isoniazid)

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6
Q

Extensively drug resistant to resistant to

A

Isoniazid & rifampin
Fluoroquinolone
(levo & Moxifloxacin)
One 2nd line injectable (amikacin, capreomycin, streptomycin)

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7
Q

Multi-drug resistant treatment

A 
5, 6, or 7 drugs 
Isoniazid 
Rifampin
Pyrazinamide 
Ethambutol 
Amikacin 
Capreomycin 
Levofloxacin 
Cycloserine
PAS
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8
Q

TB plus HIV treatment

A

Rifampin accelerates metabolism of protease inhibitors and NNRTI’s
Substitute for rifabutin

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9
Q

Latent TB treatment

A

Isoniazid , rifampin, or isoniazid + rifapentine

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10
Q

Isoniazid interactions

A 
Inhibitor of CYP enzymes
^Phenytoin
^carbamazepine
^diazepam
^triazolam
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11
Q

Isoniazid AE

A 
Peripheral neuropathy
Hepatotoxicity 
Optic neuritis, seizures, dizzy, ataxia, psychological disturbances
(Crosses BBB)
Anemia
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12
Q

Rifampin interactions

A

Induces P450, ^drug metabolism
Warfarin
BC
HIV meds (NNRTI’s)

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13
Q

Rifampin AE

A

Hepatotoxic
Orange body fluids
GI

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14
Q

Pyrazinamide AE

A 
Hepatotoxic 
Non-gouty pararthalgia
Hyperuricemia
GI
Photosensitivity
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15
Q

Ethambutol AE

A 
optic neuritis
Hyperuricemia 
Dermatitis 
Peripheral neuropathy
Renal damage
Thrombocytopenia
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16
Q

Levofloxacin and Moxifloxacin

A

???

17
Q

Capreomycin & amikacin (inj)

A

Nephrotoxic

8th CN damage-vHearing, tinnitus, vBalance

18
Q

Para-aminosalicylic acid AE

A

GI
Hepatotoxic
Goiter
^sodium loading

19
Q

Ethionamide AE

A 
Metallic taste
GI!!!
Hepatotoxic 
Peripheral neuropathy
CNS-convulsions/Mental disturbance
Allergic
Hypoglycemia
20
Q

Cycloserine AE

A

CNS effects frequent/severe
Anx,dep,conf, hallucination, paranoia, hyperreflexia, seizure, psychotic episode

Hepatotoxicity, peripheral neuropathy, vFolate

21
Q

Bedaquiline
HIV pt’s can take bc ___
^____

A

Doesnt accelerate metabolism
^QT
$36k

Pharmacology (23 decks)

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