Module 4 CNS

Question 1

Drugs for parkinsons

Answer 1

dopaminergic
anticholinergic
monoamine oxidase B inhibitor (mild sx)
catechol-O-methyltransferase (COMT) inhibitors

Question 2

Dopamine agonists

NON-ergot derivatives

Ergot-derivatives

Answer 2

NON-ergot derivatives
Pramipexole (early PD)
ropinrinole
rotigotine
apomorphine

Ergot-derivatives
bromocriptine
cabergoline

Question 3

COMT (inhibit levodopa metabolism)

Answer 3

Entacapone
Tolcapone
Levodopa/carbidopa/entacapone

Question 4

MAOB inhibitors (1st line)
(2)

Centrally acting anticholinergic drugs
(2) (2nd line tremor therapy)

Answer 4

selegiline
Rasagiline

Beztropine
Trihexyphenidyl

Question 5

antiviral effective in PD

Answer 5

Amantadine

Question 6

Alzheimers goal of treatment:reverse cog decline

drugs (4)

Answer 6

(Cholinesterase inhibitors-mild-mod AD)
donepezil
galantamine
Rivastigmine-AD+demenitia of PD

(NMDA receptor antagonist)
Memantine (mod-severe)

(Know indications for all)

Question 7

Muscle relaxants

all are sedating/ addictive**

Answer 7

diazepam
tizanidine
metaxalone (least sedating)
chlorzoxazone
cyclobenzaprine
methocarbamol
orphenadrine

Question 8

Drugs for movement disorders (spacticity)

Answer 8

baclofen
diazepam
Dantrolene-hepatic tox
tizanidine

Question 9

Epilepsy traditional AED’s

Answer 9

phenytoin
fosphenytoin
carbamazepine
valproic acid
ethosuximate
phenobarbital
primidone

Question 10

Epilepsy newer AEDs

Answer 10

better tolerated
oxcarbazapine
lamotrigine
gabpaentin, pregabalin
topiramate
tiagabine
zonisamide
felbamate 
rufinamide
ezogabine

Question 11

status epilepticus treatment

Answer 11

maintain ventilation, correct hypoglycemia
terminate seizure- benzo (lorazepam) or diazepam
initiate/cont phenytoin or fosphenytoin long term