Module 4 Drugs

Question 1

Oxybutynin

Acts on ____receptors
____lipid soluble
Metabolized by ___
Must be dosed ____ d/t ____ half life

Answer 1

Acts on M3 muscarinic receptors
Highly lipid soluble
Metabolized by cyp3a4 receptors
Dose frequently due to short half life

(OAB)

Question 2

OAB Meds 
D
S
T
F
T

Answer 2

Darifenacin-most selective (M3) & NOT M1 (brain)/ M2 (heart)

Solifenacin-^dose=^QT

(non selective muscarinic antagonists)

Tolterodine
Fesoterodine
Trospium

Question 3

Scopolamine (anticholinergic)

Use

Answer 3

motion sickness
cycloplegia/mydridriasis (procedures)
preanesthetic sedation
obstetric amnesia

Question 4

Ipratroprium bromide (anticholinergic)
Use

Answer 4

asthma, COPD, allergic rhinitis, cold

Question 5

What are mydristic cycoplegics?
(Anticholinergic)

produce mydriasis/cyclopegia for opthalmic procedures

Answer 5

atropine
homatropine
scopolamine
cyclopentolate
tropicamide

Question 6

Muscarinic poisoning cause and tx

Answer 6

direct acting muscarinic agonists, cholinesterase inhibitors

tx: muscarinic blocking agent-Atropine

Question 7

Reversible Cholinesterase inhibitor and use
(prevents degredation of acetylcholine)
(indirect cholinergic agonist)

Answer 7

Neostigmine

Question 8

Irreversible cholinesterase inhibitor

Answer 8

Toxic (pesticide)

Question 9

Why can’t catecholamines be taken orally

Adrenergic agonist

Answer 9

Inactivated by liver by the time reaches circulation
Short half life
Brief duration of action
Can’t cross bbb

Question 10

Noncatecholamines benefits

Adrenergic agonist

Answer 10

Po
Metabolized slower
Not metabolized by comt
Less polar-can cross bbb

Question 11

What is the therapeutic application for activation in alpha1-vasoconstriction
Ae?

Answer 11

hemostais
nasal decongestion
adjunct to local anesthesia
^BP
se: htn, necrosis, vHR d/t baroreceptor effect

Question 12

Alpha 2 activation=

Answer 12

(inhibits NE release)
Reduces sympathetic outflow to heart
Pain relief

Question 13

Beta 1 activation

Beta 2 activation

Answer 13

B1: ^HR, contractility=^O2 demand

B2: Lung/uterus relaxed

Question 14

Dopamine activation

Answer 14

Renal vasodilation=^perfusion

can also stimulate heart rate d/t B1

Question 15

Adrenergic agonists 
E
N
I
D
D
A
P 
E

Answer 15

Epinephrine 
Norepinephrine 
Isoproterenol
Dopamine
Dobutamine
Phenylephrine
Albuterol
Ephedrine

Question 16

Adrenergic receptors? Uses?

Answer 16

?????????????

Question 17

Alpha Adrenergic blocking agents

Answer 17

prazosin
terazosin
doxazosin
tamsulosin
alfusozin
silodosin
----------------------
nonselective-phentolamine(pheochromocytoma/extravasation)

Question 18

Alpha Adrenergic blocking agent uses

Answer 18

htn- causes vasodilation by blocking A1
bph- reduces smooth muscle contraction
raynauds-prevents contriction

Question 19

Alpha Adrenergic blocking agents SE

Answer 19

orthostatic hypotension
reflex tachycardia (baroreceptor reflex)
nasal congestion
xEjaculation
sodium retention &^Blood volume

Question 20

Beta adrenergic drugs need to be discontinued _____

Answer 20

slowly or can = rebound excitation -dysrhythmia

Question 21

Resperine

adrenergic neruon blocking agent

Answer 21

Discontinued in US