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Pharmacology > Module 4 psych > Flashcards

Module 4 psych Flashcards

1
Q

First generation antispychotics (conventional) MOA

what do they cause

A

block receptors for dopamine in CNS

cause movement disorders (EPS)

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2
Q

2nd Gen antipsychotics (atypical) moderate blockade of ____ receptors, stronger blockade for ____ receptors

A

mod blockade-dopamine
strong blockade-serotonin
Fewer EPS’s

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3
Q

antipsychotics primarily used to treat

Main SE:

A

schizophrenia

EPS

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4
Q

High potency antipsychotics

A

haloperidol

Fluphenazine

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5
Q

Low potency antipsychotics

A

chlorpromazine

thioridazine

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6
Q

Atypical antipsychotic agents

A 
olanzipine
amoxapine
mirtazapine-help w sleep
nefazodone-BBW-liver failure
Trazodone
vilazodone
Respiradone
paliperidone
ziprasidone
quetiapine
aripiprazole
asenapine
Iloperidone
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7
Q

Clozapine (atypical antipsychotic)
MOA
uses

A

moa-blocks dopamine and serotonin

uses: schizophrenia &levodopa induced pscyhosis

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8
Q

Clozapine (atypical antipsychotic) metabolism

A

metabolized by cyp450, 12hr half life

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9
Q

Depot preparations for long term maintenance therapy of

A

schizophrenia

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10
Q

schizophrenia objectives

A

suppress acute ep’s
prevent acute exc
maintain highest level of functioning

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11
Q

Schizophrenia tx in pt w hx of DM, hld

A

FGA(v$)or 2 sga’s: aripiprazole or ziprasidone (vrisk for metabolic effects)

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12
Q

First choice drugs for depression

A

SSRI’s, SNRI’s, bupropion, mirtazapine

2nd: TCA’s/Maoi’s

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13
Q

SSRI’s

A 
Fluoxetine
sertaline
fluvoxamine-long half life
paroxetine
citalopram-^QT
escitalopram
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14
Q

SNRI

A

venlafaxine
desvenlafaxine
duloxetine
levomilnacipran

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15
Q

Levomilnacipran (SNRI)

A

block reuptake of serotonin and Ne

SE: hyponatremia

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16
Q

Tricyclics SE:

Long half lifes=single dose

A

sedation
orthostatic hypotension
anitcholinergic effects

17
Q

Tricyclics

A 
amitriptyline
amoxapine
desipramine
dozepin
imipramine
nortriptyline
protriptyline
trimipramine
18
Q

MOAI’s

A

isocarboxazid
phenelzine
tranylcypromine
selegiline

19
Q

MOAis used as last resort, se?

A

hypertensive crisis/dietary tyramine

20
Q

Bupropion (Atypical) use

se:

A

smoking cessation , counteract sexual dysfunction w SSRI

SE: vAppetite, ^seizure risk

Pharmacology (23 decks)

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