(QUIZ) Fluoroquinolones/azole

Question 1

What bacteria is resistant to ciprofloxacin

Answer 1

Neisseria Gonorrhoeae

Question 2

Why is N. Gonorrhoeae resistant to Ciprofloxacin

Answer 2

???????

Question 3

Ciprofloxacin AE

NOT FOR PRGNCY

Answer 3

Tendon rupture
AAA
Photosensitivity 
CNS:confusion ^elderly
Cdiff risk
BBW!!! MG muscle weakness

Question 4

Ciprofloxacin reduced by

Answer 4

Aluminum/mag antacids
Zinc/iron salts
Sucralfate
Milk/dairy

Question 5

Ciprofloxacin elevates

Answer 5

Theophylline (asthma)
Warfarin
Tinidazole

Question 6

Metronidazole & Tinidazole use

Gut/vag infections

Answer 6

Protozoal infections
Obligate anaerobes (surgery)
H.pylori 
Cdiff
Trich
Bv
Giardiasis

Question 7

Metronidazole &Tinidazole SE

do not use in 1st trimester

Answer 7

Neurotoxicity 
Allergy
Superinfection
Disulfiram effect w alcohol (weeks)
CA rats
darken urine
nausea, dry mouth, metallic taste

Question 8

What is initial cdiff treatment?

Answer 8

Fidaxomicin

Question 9

Eye ointment

___ &____

Answer 9

Bacitracin

Polymyxin B

Question 10

(Antifungal)
Amphotericin
-drug of choice for

Answer 10

Systemic mycoses

Question 11

(Antifungal)

Amphotericin MOA

Answer 11

Binds to ergosterol in fungal cell membrane

^permeability =leaks intracellular cations (K)

Question 12

(Antifungal)

Amphotericin AE

Answer 12

Fever, chills, HA
Nephrotoxic
Hypokalemia
Bone marrow suppression

Question 13

(Antifungal)
Azoles
-alternative to ____ for systemic mycoses
-inhibits ___=^____

Answer 13

Amphotericin

(Lower toxicity)

Inhibits p450=^other drug levels

Question 14

Itraconazole MOA

Answer 14

Inhibits synthesis of ergosterol by inhibiting fungal p450 dependence enzymes

Question 15

Itraconazole SE

Answer 15

vEF
Liver damage
P450 inhibition
N/v/d

Question 16

(Echinocandins) [-fungins]

Caspofungin MOA

Answer 16

Inhibits biosynthesis of B1,3-4-glucan (part of fungal wall)

Question 17

(Echinocandins)

Caspofungin AE

Answer 17

Systemic candida
Pleural space infections
Intraabdominal abscesses

Question 18

(Pyramidine Analog)

Flucytosine use

Answer 18

Serious candida and cryptococcus neoformans

Question 19

(Pyramidine Analog)

Flucytosine AE

Answer 19

Prolonged 1/2 life w renal insufficiency
BBW!!! Fatal agranulocytosis-Myelosuppression
Hepatotoxicity- ^1/2life of drugs

Question 20

Trimethoprim/sulfamethoxazole (antimetabolite) inhibits
used for:
children-dose based on trimethroprim

Answer 20

folic acid synthesis

CAMRSA, UTI, listeria, Silvadene-burns

Question 21

Trimethoprim/sulfamethoxazole AE

Answer 21

skin rxcn^
vBS esp w vRenal fx
G6PD-hemolytic anemia
kernicterus
^K
crystalluria=renal damage
megaloblastic anemia, thrombocytopenia

Question 22

Trimethoprim/sulfamethoxazole cross rxcn

Answer 22

thiazides, loop diuretics, celebrex, sulfonylureas

Question 23

Quinolones moa

coverage gram:

Answer 23

inhibit DNA gyrase (bactericidal)

gram +/- (empiric therapy)

Question 24

Quinolones first generation :

used for:

Answer 24

ciprofloxacin

pyelo/uti, intractable diarrhea

Question 25

Quinolones 2nd gen: (2 meds) used for

Answer 25

levofloxacin- resp/uti/pyelo/prostatitis, diarrhea

ofloxacin-eye, ear, skin, lungs, prostate, uti

Question 26

Quinolones 3rd gen and use (3)

Answer 26

moxiflacin- resp tract infection
norfloxacin-prostate, uti, gonorrhea
gemifloxacin- respiratory infections, CAP

Question 27

Quinolones 4th gen

Answer 27

delafloxacin-skin

Question 28

synthetic fluoroquinolone used for gram neg uti:__

can cause _____erosion

Answer 28

nadilixic acid

cartilage erosion

Question 29

Topicals for impetigo

Answer 29

muciprocin
retapamulin
ozenoxacin
bacitracin
polymyxin