ANtivirals

Question 1

Acyclovir

1st choice for ___&___

Answer 1

Herpes & varicella Zoster(VZV)

Question 2

Acyclovir SE
IV:
PO:
Topical:

Answer 2

IV:Nephrotoxic/neurotoxic
PO: preg safe, n/v/d, HA, vertigo
Topical: stinging/burning

Question 3

Valacyclovir reduces what

Answer 3

Transmission of genital herpes

Question 4

Valacyclovir SE:

Answer 4

Immunocompromised=

Thrombotic thrombocytopenic purpura/hemolytic uremic syndrome (TTP/HUS)

Question 5

Famciclovir use

Answer 5

Herpes zoster or Genital

Question 6

Famciciclovir SE

Answer 6

Minimal, ^doses=Acute renal failure

Question 7

Ganciclovir uses (3)

Answer 7

Herpes simplex
CMV for immunocompromised treatment/prevention
Indefinite maintenance therapy

Question 8

Ganciclovir SE (3)

Answer 8

Reversible Myelosuppression (granulo/thrombocytopenia )
Reproductive toxicity
Nausea, rash, liver, confusion (CNS)

Question 9

Valganciclovir use (2)

Answer 9

CMV retinitis

Prevent CMV in high risk organ transplant pt’s

Question 10

Cidofovir use

Answer 10

IV for cmv retinitis in pt’s w AIDS who failed ganciclovir or foscarnet

Question 11

Cidofovir SE

Answer 11

Nephrotoxicity
Neutropenia
Ocular disorders (iritis,uveitis, ocular hypotony)