(QUIZ) Aminoglycosides Flashcards
1
Q
Aminoglycosides MOA
Bactericidal
A
Cause misreading of code on mRNA to inhibit protein synthesis =rapid death
2
Q
Aminoglycosides
G
T
A
A
Gentamicin Tobramycin Amikacin (broadest) Neomycin Kanamycin (^resistance) streptomycin paromomycin
3
Q
Aminoglycosides susceptible pathogens ((((Aerobic - bacilli )))) P K S P
A
Pseudomonas
Klebsiella
Serratia
Proteus
4
Q
Aminoglycosides AE
Monitor Peak/Trough- 2 & 12 hours after dose
A
Ototoxicity Nephrotoxicity Blood dyscrasia Teratogenic Neuromuscular blockade (MG/anesthetics)
5
Q
Sulfonamides MOA
A
Suppresses growth by inhibiting tetrahydrofolic acid
= unable to = DNA/RNA proteins
6
Q
Sulfonamide primary use___
Also ___
A
UTI’s
Gram (-) bacilli Nocardiosis Listeria Chlamydia Toxoplasma/malaria Pneumocystitis Jiroveci UC Burns
7
Q
Sulfonamide AE
A
SJS Blood dyscrasia Kernicterus Renal damage d/t crystaluria Rash/fever/photosensitivity
8
Q
Sulfonamide blood dyscrasias
A
G6PD (black/Mediterranean) = hemolytic anemia = fever,pallor, jaundice
Agranulocytosis, leukopenia, thrombocytopenia, aplastic anemia
9
Q
Sulfonamides inhibit hepatic metabolism of W P H S
A
Warfarin
Phenytoin
Sulfonyl-urea
Hypoglycemics
10
Q
Aminoglycosides used with (3)
A
PCN
Cephalosporins
vanc
