HEp/flu/hiv Flashcards
Hepatitis medications (4)
Protease inhibitors
Interferon Alpha and Ribarvirin
NS5A inhibitor
NS5B inhibitor
Hepatitis B medications
Alfa interferon (subQ) Nucleoside analogs
Influenza medications
Neuraminidase inhibitors (w/in 48hrs)
Zanamivir
Oseltamivir
Peramivir
5 classes of antivirals for HIV
Reverse transcriptase inhibitors Integrase strand transfer inhibitors Protease inhibitors Fusion inhibitor CCR5 antagonist
NRTI name & MOA
Zidovudine- suppresses synthesis of viral DNA
Zidovudine SE
NRTI
Hematologic toxicity Lactic acidosis w hepatomegaly Myopathy CNS Pancreatitis
NNRTI 1st line drug & MOA
Efavirenz-bind to center of reverse transcriptase and =direct inhibition
Efavirenz
(NNRTI) SE:
(^interactions[p450inhibitor/inducer])
Transient CNS sx in 50%
Teratogen
Liver damage
Rash
NNRTI’s
Efavirenz Nevirapine Delavirdine Eltravirine Rilpivirine
Integrase strand transfer inhibitor SE
Rhabdomyolysis
FDA pregnancy risk
^liver enzymes (amylase/lipase)
XXXmetabolized by P450=vInteractions
Protease inhibitors SE
Hyperglycemia Fat redistribution ^bleeding w hemophilia vBone mineral density ^transiminase vConduction velocity (^interactions[metabolized by P450])
Fusion inhibitor
name?
SE?
Enfuvirtide
Inj site rxcn, PNA, hypersensitivity
NO significant drug interactions
CCR5 antagonist
Name?
SE?
Interactions d/t
Maraviroc
Dizzy,pyrexia, rash, abd pain, msk, URI
(Levels affected by CYP3A4 ind/inh)
Lab tests to guide HIV tx (2)
Genetic (2)
CD4 count
HIV RNA
HLS-B5701-abacavir sensitivity
CCR5 tropism-responsiveness to miravoc
What causes resistance to HIV tx
HIV reverse transcriptase makes a lot of errors when transcribing RNA->DNA=rapid resistant mutation
