Module 5 CV/renal drugs pt 2

Question 1

Agents that act on vascular smooth muscle and the heart (CCBs) (2)

Answer 1

verapamil

diltiazem

Question 2

Group of agents that act mainly on vascular smooth muscle (CCB) (1)

Answer 2

Dihydropyridines

nicardipine, amlodipine, isradipine, felodipine, nimodipine, nislodipine

Question 3

blocking calcium channels = ____ prevention and _____

Answer 3

contraction prevention and vasodilation

Question 4

How does calcium affect AV node conduction

Answer 4

open channels=AV nodes readily discharge

Closed channels=AV node discharge is suppressed= vVelocity

Question 5

What are 3 chemical families of CCB? examples?

Answer 5

dihydropyridines - nifedipine

non-dihydropyridines-verapamil

Question 6

How do verapamil and diltiazem reduce arterial pressure? (CCB)

Answer 6

blockade at peripheral arterioles

Question 7

How do verapamil and Diltiazem increase coronary perfusion? (CCB)

Answer 7

blockade at arteries and arterioles of the heart

Question 8

How do Verapamil and diltiazem reduce heart rate? (CCB)

Answer 8

blockade at SA node

Question 9

How do verapamil and diltiazem decrease force of contraction? (CCB)

Answer 9

blockade in the myocardium

Question 10

Verapamil/diltiazem uses? (CCB)

se?

Answer 10

angina, htn (2nd line), dysrhythmias-a flutter,afib,svt

AE intensified by beta blockers

Question 11

Nifedipine is limited to blockade of CA channels in _____

Answer 11

vascular smooth muscle

Question 12

Nifedipine (CCB) works on channels of vascular smooth muscle- has no direct effects on (3)

Answer 12

automaticity
AV conduction
Contractile force
(cancelled out by baroreceptor reflex)

Question 13

Nifedipine (CCB) use?

se?

Answer 13

use: angina, htn
se: flushing, dizzy, ha, edema, gums, chronic rash in geri’s
AE’s decreased by beta blockers

Question 14

vasodilators (3)

Answer 14

Hydralazine
nitroglycerine
prazosin

Question 15

Vasodilators uses?

se?

Answer 15

htn, htn crisis, angina, HF, MI

se: hypotension