Module 4 PNS Flashcards
What are basic mechanisms by which neuropharmacologic agents act
- sites of action: neuron vs synapse
- steps in synaptic transmission;
- effects of drugs on the steps of synaptic transmission
4 Steps of transmission
- transmitter synthesis
- Transmitter storage
- Transmitter release
- Receptor Binding
Epinephrine can activate all receptors except
dopamine
Norepinephrine can activate alpha 1 &2, and beta 1 receptors but not ___ or ___ receptors
Beta2 or domapine recpetors
Dopamine can activate which 3 receptors
alpha1, beta1, and dopamine receptors
Selectivity of neuropharmacologic drugs are
high selectivity
3 functions of ANS
regulates heart
regulates secretory glands
regulate smooth muscle
What are the regulatory functions of parasympathetic NS?
- slows heart
- ^gastric secretion
- emptying bladder
- emptying bowel
- focusing eye for near vision
- constricting pupil
- constricting bronchial smooth muscle
What are functions of sympathetic NS?
- regulates CV system (to brain, vasoconstrict)
- regulate temp (sweat/piloerection)
- implementation of fight or flight
What is baroreceptor reflex
receptors near heart monitor BP, send info to brain, brain activates ANS=constriction/dilation
Where is acetylcholine employed
@ most junctions of peripheral nervous system
Where is epi and norepinephrine released
Epinephrine-released by post-ganglionic neurons
Norepinephrine-released by adrenal medula
What are cholinergic receptors mediated by?
What are subtypes?
Cholinergic receptors mediated by acetylcholine
SUBs: nicotinic & muscarinic
What are Adrenergic receptors mediated by?
What are the subtypes?
Adrenergic receptors mediated by epi/ne
SUBS: alpha 1 &2, beta 1&2, dopamine
What are the functions of subtypes: Alpha 1 Alpha 2 (no significance) Beta1 Beta 2 Dopamine
Alpha1-Vasoconstriction, ejaculation, contraction of bladder neck and prostate
Beta1-^HR,Contraction, AV conduction; renin release
Beta2-bronchial dilation, vasodilation, relax uterus, glycogenolysis
Dopamine-dilates renal blood vessels