Module 5 antiplt

Question 1

Drugs that activate antithrombin

Answer 1

heparin (unfractionated)

enoxaPARIN (lmw heparin)- preg, dvt, bridge warfarin therapy, HIT

Question 2

Vitamin K antagonist

Answer 2

warfarin

Question 3

Direct thrombin inhibitor

Answer 3

dabigatran-rev: praxabind
argatroban-dvt in pts w HIT
Bivalirudin-PCI
Desirudin-PCI

Question 4

Direct factor XA inhibitors

CHA2D22VASc 2+ needs this

Answer 4

fondipirinox-DVT/PE, HIT
rivaroxaban-Rev:andexa
apixaban --rev:andexa
edoxaban 
bevyxxa-DVT

Question 5

G2b/3A receptor agonist

Answer 5

abciximab
eptifibatide
tirofiban
(inhibit final step in plt aggregation for pts w PCI)

Question 6

G2b/3A medication for intermittent claudication

Answer 6

cilostazol

Question 7

thrombolytics

Answer 7

tenecteplase
reteplase
alteplase-tPA
(remove thrombi already formed-MI/PE/stroke)

Question 8

STEMI MONABB

Answer 8

morphine-^hemodynamics (venodilation-vPreload)
Nitro-vPreload, vO2 demand, ^bloodflow to heart, htn, limit infarct size, LV Function
ASA-reduces mortality
BB-vO2 demand, pain, infarct size, short term mortality, recurrent ischemia/reinfarction

Question 9

what drugs are used for reperfusion therapy

Answer 9

fibrinolytic( thrombolytics)

tenecteplase, reteplase, alteplase

Question 10

door to baloon time stemi

Answer 10

90 min