Quiz 3 Pancreas Flashcards
light staining spherical clusters that produce hormones
islet of Langerhans
alpha cells secrete
glucagon
beta cells secrete
insulin and amylin
delta cells secrete
somatostatin
enterochromaffin cells secrete
serotonin
insulin effects on islet cells
activates beta cells and inhibits alpha cells
glucagon effects on islet cells
activates alpha cells and then alpha cells activate delta cells
somatostatin effect on islet cells
inhibits alpha and beta cells
1 type of primary DM
DM2 (85-95%)
2 type of DM
DM1 (5-10%)
3 type of DM
DM1.5 (5%)
Autoimmune disease with islet destruction by immune cells reacting to endogenous b-cell antigens
Type 1 DM
antibodies to DM1
anti-islet cell Ab
anti-insulin Ab
Presence of lymphocytic infiltrates in the islets of Langerhan suggests what?
suggests autoimmune mechanism (DM1)
Insulin resistance and decreased production of insulin by B cells
DM2
Pink hyalinization and amyloid deposition in the islets of langerhans
DM2
1 cause of vision loss due to retinopathy
diabetic retinopathy
dilated capillaries, micro aneurism lead to leaked RBC leads to retinal hemorrhage, edema, exudate
non-proliferative diabetic retinopathy
lack of oxygen to retina leads to development of fragile new blood vessels that lead to retinal detachment
proliferative diabetic retinopathy
earliest detectable change is thickening of capillaries within glomeruls, then nodular glomerulosclerosis
diabetic retinopathy
pacreatic tumor derived from beta cells that secretes gastrin and leads to excess HCL and ulcerations
gastrinoma
1 location of gastrinoma
duodenum
triad of gastric acid hyper secretion, severe peptic ulceration, and gastrinomas of pancreas or duodenum
Zollinger-Ellison Syndrome
