Psychopharmacology Flashcards
what is an agonist
a drug that facilitates the effects of a particular neurotransmitter on postsynaptic cell
inhibits inhibitoru neurotransmitter
what is an antagonisy
drug that inhibits the effect of partivular neurotransmitter on postsynaptic cell
inhibit excitatory neuron
what is apomoprhine
an agonist and antagonist
what are pre-synaptic auto receptors
have a high affinity for apomorphine ; even at low doese many are activated and act as antagonist
at high doses apomorphine binds with postsynaptic receptors acting as an agonist
what is GABA
glutamate and gamma-aminobutyric acid
most common neurotransmitter in brain
what are 4 types of glutamate receptor
NMDA
kainate
AMPA
metabotropic glutamate
what are two types of GABA
GABAa and GABAb
what is neural integration
excitatory and inhibitory signals are combined from glutamate and GABA inputs
what are two acetylcholine receptors
nicotinic(ionotropic) and muscarinic (metabotropic)
what are the three main Ach systems
basal forebrain
dorsolateral pons#
medial septum
what are the dorsolateral pons
only small number but project all over brain- influences thalamus
what is radial arm maze experiment
baited arm and non-baited arm
showed that rats with cholinergic lesions of dorsolateral pons cannot learn association
what is themedial septum
involved in learning and memory, controls rhythms in LFP forebrain
what is basal forebrain
provides large input to cortex and has a role in learning and attention
what are the three main dopamine systems in brain
nigrostriatal etc
