Olfaction Flashcards

1
Q

three points about smelly molecules

A

small volatile hydrophobic

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2
Q

what are the feautres that disrupt flow of air through nose

A

turbinates

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3
Q

what does air first come into contact with in nose

A

epithelium

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4
Q

what do odours bind t

A

stick to epithelium and bind to olfactory cilia

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5
Q

what are olfactory cilia part og

A

olfactory sensory neuron

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6
Q

what is a feature of OSN

A

each have a single type of odour receptor

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7
Q

what are two theories of smell

A

shape theory vibration theory

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8
Q

what is shape theoru

A

shouldnt be difference in smell in ispotopes

changing shape of molecule doesnt change the smell

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9
Q

what is vibration theory

A

molecules with same iR vibrational spectrum smell similar

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10
Q

when do OSN fire

A

after 8 sites filled

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11
Q

where are OSN signals sent

A

olfactory bulb

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12
Q

why is olfaction different to other senses

A

no thalamus

direct line to cortex

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13
Q

where do axons on OSN project

A

to glomerulin in olfactory bulb

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14
Q

what are the 3 areas where smell generate a pattern of activity

A

entorhinal
piriform
cortex

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15
Q

what are three areas the olfactory bulb projects to

A

piriform cortex
amygdala
entohinal cortex= orbitofrontal and frontal cortex

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16
Q

describe blindsmell

A

does the brain respond to odours in concentrations below perceptual thrsholds?
fMRI used and found brain activation

17
Q

what is the vNO

A

vomersonasal organ and is parallel olfactory system

18
Q

describe the VNO

A

contains seperate set of heavy chain odorant receptors that bind pheromones

19
Q

what is MHC

A

major histocompatabiloty complex - in mice

20
Q

what is HLA

A

human leukocyte antigen in humans

21
Q

what is androstadienone

A

metabolite of testosterone found in sweat

22
Q

how are pheromones detected

A

second class of receptors in mouse olfaction epithelium- also in humans

23
Q

what happens if something pushes your cribiform plate back

A

shear all the OSN axons making you anosmic

24
Q

what is the McClintock effect

A

reported that female students who live together synchronised period
could be driven by pheromones