Olfaction Flashcards
three points about smelly molecules
small volatile hydrophobic
what are the feautres that disrupt flow of air through nose
turbinates
what does air first come into contact with in nose
epithelium
what do odours bind t
stick to epithelium and bind to olfactory cilia
what are olfactory cilia part og
olfactory sensory neuron
what is a feature of OSN
each have a single type of odour receptor
what are two theories of smell
shape theory vibration theory
what is shape theoru
shouldnt be difference in smell in ispotopes
changing shape of molecule doesnt change the smell
what is vibration theory
molecules with same iR vibrational spectrum smell similar
when do OSN fire
after 8 sites filled
where are OSN signals sent
olfactory bulb
why is olfaction different to other senses
no thalamus
direct line to cortex
where do axons on OSN project
to glomerulin in olfactory bulb
what are the 3 areas where smell generate a pattern of activity
entorhinal
piriform
cortex
what are three areas the olfactory bulb projects to
piriform cortex
amygdala
entohinal cortex= orbitofrontal and frontal cortex
describe blindsmell
does the brain respond to odours in concentrations below perceptual thrsholds?
fMRI used and found brain activation
what is the vNO
vomersonasal organ and is parallel olfactory system
describe the VNO
contains seperate set of heavy chain odorant receptors that bind pheromones
what is MHC
major histocompatabiloty complex - in mice
what is HLA
human leukocyte antigen in humans
what is androstadienone
metabolite of testosterone found in sweat
how are pheromones detected
second class of receptors in mouse olfaction epithelium- also in humans
what happens if something pushes your cribiform plate back
shear all the OSN axons making you anosmic
what is the McClintock effect
reported that female students who live together synchronised period
could be driven by pheromones
