Protein Flashcards
Procalcitonin is measured using _____ and is elevated in _____ infections.
immunoassays
bacterial
Procalcitonin is used to diagnose and monitor _____
sepsis
An acute phase protein important for elasticity in lungs is ______
alpha1-antitrypsin
Decreased concentrations of _____ can cause liver & hepatocellular damage
alpha1-antitrypsin
Alpha1-acid glycoprotein is a ______ protein
binding protein for many drugs
Alpha2 globulins
Haptoglobulin
Ceruloplasmin
Haptoglobulin binds ______ and is monitored in ______ disease
free hemoglobin
Hemolytic disease
Ceruloplasmn binds to ______ and is important in storing abilities of ______
Copper
Ferritin
CRP is s ____ globulin
gamma
What is the most sensitive acute phase reactant?
Gamma globulin
Which globulin is a prognostic indicator of future adverse cardiac events?
Gamma globulin
Transferrin is ______ in iron deficiency and _____ in iron overlaod
Elevated:
Iron Deficiency
Decreased:
Iron Overload
Which globulin is increased as a part of late, positive acute phase reaction?
C3 complement (a B2 globulin)
Which are the negative acute phase reactants?
Albumin
Prealbumin
Transferrin
Which compound looks like a monoclonal immunoglobulin, but does not show up as an immunoglobulin on immunofixation electrophoresis?
Fibrinogen
Which immunoglobulins are not present at sufficient concentrations to be detected by SPEP?
IgD
IgE
Indicators of multiple myeloma (MM) following a bone biopsy:
30%+ of cells are identified as plasma cells
OR
3+ lytic regions
Bone marrow lesions in multiple myeloma look “____”, `
“Punched out”
CRAB
Multiple myeloma:
Calcium in excess
Renal injury
Anemia
Bone pain
Which disease is characterized by IgM monoclonal proteins causing hyperviscosity of the serum?
Waldenstrom’s macroglobulinemia
10% of patients with Waldenstrom’s macroglobulinemia experience _____
Bence-Jones proteinuria
Which syndrome lacks bone disease and tenderness?
Waldenstrom’s macroglobulinemua
What is monoclonal gammopathy of undetermined significance? (MGUS)
Presence of an M-protein in persons w/o clinical evidence of MM, macroglobulinemia, or primary amyloidosis (AL).
Makes up 50-60% of M-protein having patients
How does MGUS prevalence change?
Frequency increases with age and in African Americans and Japanese
