Lab Med 46-60 Flashcards
What are the aminoglycosides?
Amikacin
Gentamicin
Tobramycin
What are the basic functions of the liver?
Synthesis
Catabolism
Detoxification
What are the estrogen and progesterone receptors? Where are they found? What are they used for?
Hormone markers
Cytosol form breast tumor tissue
if positive = patient will respond to hormone therapy
What are the goals for INR?
Normal = 0.9-1.5
Coumadin therapy = 2-3
High risk = 2.5-3.5
What are the signs of aminoglycoside toxicity? Treatment?
Ototoxic
Nephrotoxic
Discontinue
What are the signs of amphetamine overdose? Treatment?
"HAHA Paul" Hypertension Arrhythmias Hyperthermia Agitation Paranoia
Supportive care
What are the signs of carbamazepine toxicity?
“BAN”
Blurred vision
Ataxia
Nystagmus
Hematological depression (not dose dependent) Accumulation of carbamazepine-10-11-epoxide in kids
What are the signs of cocaine overdose?
CAD
Unidirectional heart block
Norepinephrine stimulation
Hyperthermia
What are the signs of digoxin toxicity?
The 5 V's Vomiting/nausea Visual disturbances (green/yellow) premature Ventricular contractions Ventricular tachycardia atrioVentricular node block
What are the signs of ethosuximide toxicity? Treatment?
GI distress
Lethargy
Dizziness
Discontinue
What are the signs of phenobarbtial toxicity? Treatment?
"CASS" CNS depression Ataxia Slurred speech Sedation
Discontinue
What are the signs of phenytoin toxicity?
"Dah ANTS" Drowsiness Ataxia Nystagmus Tremors Seizures --> chronic use of gingival hyperplasia
What are the signs of primidone toxicity? Treatment?
"DANC V" Dizziness Ataxia Nausea CNS depression Vomiting
Discontinue
What are the signs of procainamide toxicity? Treatment?
"A QAB" AV block QRS interval prolongation Arrhythmias Bradycardia
Discontinue
What are the signs of salicylate overdose?
Metabolic acidosis Tinnitus Hyperthermia Hyperventilation CNS
