Lab Med 226-240 Flashcards
What is theophylline?
A methylxanthine used to treat asthma
PK is age dependent
What is therapeutic drug monitoring?
A strategy where a patient’s dosing schedule is modified based on measurement of serum drug concentrations
What is thyroglobulin used for?
To monitor thyroid cancer recurrence post thyroidectomy
*only FDA-approved serum marker
What is thyroglobulin? Where is it found?
Immunoglobulin produced in the thyroid gland
Found in serum
What is TIBC?
Total Iron Binding Capacity
The max amount of iron that serum proteins can bind
What is transcortin?
A protein that binds 80% of cortisol –> the remaining is free and active
What is urinary free cortisol used for?
Diagnosis of Cushing’s syndrome
Cannot use to assess Addison’s
What is valproic acid? What is its absorption like
GABA transaminase inhibitor
Rapidly and completely absorbed
What is vancomycin?
Complex glycopeptide antibiotic effective against gram positive
What is warfarin?
An anticoagulant drug that inhibits vitamin K –> inhibits carboxylation of IX X VII II
What results if liver function is completely lost?
Death within hours
What subunits make up hemoglobin?
4 alpha and 2 beta
What test is best in determining sick euthyroid syndrome?
TSH (however not absolutely reliable)
What tests are used to determine biliary tract disease?
ALP, GGT, and bilirubin (total and conjugated)
What tests are used to determine hepatocellular damage?
AST, ALT, and bilirubin (total and conjugated)
