Lab Med 151-165 Flashcards
What is hemolysis?
An autoimmune hemolytic anemia that results from antibodies against RBC antigens
What is hemolytic disease of newborns?
Incompatibility between Rho of mom and baby
If mom negative = form antibodies against positive baby
What is hemosiderosis?
Iron overload without tissue injury
What is hemostasis? stages?
The process of stopping bleeding
- Vasoconstriction
- Platelet plug
- Coagulation cascade
What is heparin?
An anticoagulant that inhibits II, IX, and X by activating antithrombin III
What is Her2/neu? What is it used for?
Human Epidermal Growth Factor Receptor
To determine the response to Herceptin therapy in breast cancer
What is macrocytic anemia associated with?
Defective nuclear maturation (rise in MCV)
Pernicious anemia
Folate deficient anemia (alcoholism)
What is microcytic anemia associated with? (5)
Iron deficiency Low ferritin Low % Fe sat High TIBC Low MCV
What is neonatal thyroid screening?
Measurement of total T4 to determine hypothyroidism
Follow-up with TSH to confirm primary
What is normocytic anemia associated with?
Acute blood loss
Hemolyticanemia
Autoimmune Chronic disease/
renal failure
What is partial thromboplastin time? How is it performed?
The time it takes for a clot to form
Exposing blood to a negative charge and measuring time
What is phenobarbital? What kind of absorption does it have?
An antiepileptic that hyperpolarizes GABAa
Slow, complete absorbtion
What is phenytoin? What kind of PK does it have?
An antiepileptic drug that has zero-order kinetics
What is primidone?
Prodrug to phenobarbital
Rapid and complete absorption
What is procainamide? Where does it accumulate?
Antiarrhythmic with NAPA –> accumulates in kidney
