Lab Med 1-15 Flashcards
Do ALT or AST elevations persist longer?
ALT
How are proteins assessed in liver disease?
Total protein = normal
Direct assessment of albumin is the most useful
How can TSH differentiate between primary and secondary hypothyroidism?
Elevated = primary (thyroidal) Low = secondary (pitiutary)
How can you differentiate between primary and secondary hyperaldosteronism?
Primary (Conn’s) = low renin
Secondary = high renin
How can you differentiate the source of ALP?
Heat stability bone < intestine < liver < placenta, Regan isoenzyme "Bone burns and liver lives" High GGT
How does impaired gut absorption relate to liver disease?
Increases severity –> inability to absorb fat soluble substances –> no vitamin K –> no coag
How does leukemia affect white blood cells?
Total can increase, decrease, or not change Neutrophils increase (immature cells)
How does the thyroid secrete hormone?
Hypothalamus releases TRH –> pituitary releases TSH –> thyroid releases T4 (some T3) –> Tissues convert T4 to T3 –> negative feedback on hypothalamus
How is a clot localized?
Thrombomodulin makes II to activate protein C –> C + S = inactivation of V and VIII
Heparan activates antithrombin III = inhibition of II and X
XII activates plasmin = digest clot
How is a platelet plug form?
Tissue injury stimulates vWF binding to collagen and platelets
Displays factor Va
How is a TRH-TSH stimulating test interpreted - TSH inc in first 30 min then falls?
normal
How is acetaminophen toxicity treated?
Activated charcoal N-acetylcysteine
How is benzodiazepine toxicity treated?
Flumazenil –> do not use if patient has taken a TCA
How is bilirubin measured in amniotic fluid?
By direct spectrophotometry If mixed with blood use chloroform to clear sample
How is bilirubin transported?
In the unconjugated form bound to albumin from spleen to liver
