Prokinetic Flashcards
What are 2 prokinetic drugs?
metoclopramide
erythromycin
What is metoclopramide (Reglan)?
Dopamine D2 receptor antagonist
It suppresses the inhibitory effects of dopamine on cholinergic smooth muscle contractions along the GI tract.
What is the MoA of metoclopramide?
It suppresses the inhibitory effects of dopamine on cholinergic smooth muscle contractions along the GI tract.
What conditions is metoclopramide used to treat?
Delayed gastric emptying conditions due to diabetic gastroparesis and GERD
What are the side effects of metoclopramide?
Sedation, diarrhea, and irreversible tardive dyskinesia if used long-term
Tardive dyskinesia can occur after prolonged use and requires gradual weaning.
What class of drug is erythromycin?
(thinking as a prokinetic)
Motilin receptor agonist
What is the function of erythromycin in gastrointestinal motility?
Motilin receptor agonist that triggers smooth muscle contractions along the GI tract
It promotes gastric emptying before endoscopy.
What is a significant interaction of erythromycin?
Big CYP inhibitor
This means it can significantly affect the metabolism of other drugs processed by cytochrome P450 enzymes.
What role does PNS/cholinergic tone play in gastrointestinal motility?
Enhanced motility
The parasympathetic nervous system increases cholinergic activity, promoting movement in the GI tract.
How does dopamine receptor activity affect gastrointestinal motility?
Inhibits cholinergic actions
Dopamine serves to balance the enhancing effects of the PNS/cholinergic tone.
