General Anesthetics Flashcards
What is propofol?
GABA stimulant
A general, IV anesthetic with rapid onset of action and ultra-short duration of action
Used for the induction and maintenance of general anesthesia; induces respiratory depression; low therapeutic index.
How does propofol produce its effects?
By enhancing the release of GABA, inhibiting sodium channels, or activating the endocannabinoid system throughout the CNS
GABA is an inhibitory neurotransmitter.
What is isoflurane?
GABA receptor activator
A general, inhalation anesthetic with global CNS depressant effects
Produces loss of consciousness, analgesia, amnesia, and suppression of peripheral sensations.
What are the effects produced by isoflurane and etomidate?
Activation of GABA receptors throughout the CNS
GABA is an inhibitory neurotransmitter.
What class is etomidate?
GABA receptor activator
What is etomidate used for?
Induction of general anesthesia and sedation for short procedures
Suitable for procedures like reduction of dislocated joints, tracheal intubation, and cardioversion.
What is ketamine?
An NMDA receptor antagonist
acts on many receptors but mostly NMDA
NMDA is a subtype of an excitatory receptor for glutamate.
What are the uses of ketamine?
Starting and maintaining anesthesia, sedation in intensive care, analgesia, and treatment of ** bronchospasms**
It is also advised to give some** versed **to prevent vivid dreams.
Fill in the blank: Propofol may produce its effects by enhancing the release of _______.
GABA
What is the main advantage of etomidate over propofol?
It can be used for people who can’t handle the cardio-suppressive effects of propofol.
