Non-opioid txt of withdrawal

Question 1

What is lofexidine?

Answer 1

An alpha2a adrenergic receptor agonist

Question 2

What is the primary mechanism of action of lofexidine?

Answer 2

Inhibits the release of norepinephrine in the central and peripheral nervous system

reducing some of the symptoms of opioid withdrawal (tremors, sw

but it has no documented effect on drug craving and endogenous opioid levels

Question 3

What symptoms does lofexidine help reduce during opioid withdrawal?

Answer 3

Tremors, sweating, chills, stomach cramps, muscle pain, and rhinorrhea

Question 4

Does lofexidine have an effect on drug craving?

Answer 4

No documented effect on drug craving

Question 5

What is one of the uses of lofexidine besides opioid withdrawal?

Answer 5

Treatment of postmenopausal hot flushes

Question 6

Fill in the blank: Lofexidine is used to alleviate the _______ symptoms of heroin and other types of opioid withdrawal.

Answer 6

[physical]

Question 7

True or False: Lofexidine can be used to treat opioid/methadone dependence.

Answer 7

True