Bronchodilators Flashcards
What class of drug is theophylline?
cAMP PDE inhibitor
This prevents the breakdown of cAMP.
What is the mechanism of action of theophylline?
Inhibition of cAMP PDE, which reduces the metabolism of cAMP and allows for its accumulation, inducing smooth muscle relaxation and bronchodilation
This prevents the breakdown of cAMP.
➡️ More cAMP = more bronchodilation, because cAMP reduces intracellular calcium and relaxes smooth muscle.
What are the primary uses of theophylline?
Bronchodilator: txt of asthma and increasing rates of respiration in pre-term infants
theophylline can be used to treat patients who are unresponsive to albuterol
How can theophylline increase RR of pre-term infants?
increases sensitivity of respiratory control center to pCO2
In emergency situations, what drug can be administered to children experiencing an asthmatic attack?
Terbutaline SQ
This helps open their airways so they can respond to inhaled albuterol.
What type of drug is albuterol?
Short-acting beta-2 adrenergic receptor agonist (SABA)
Used as a bronchodilator in the treatment of asthma.
What are the primary uses of albuterol?
Bronchodilation in the treatment of asthma
Be aware of other medications the patient takes that can interfere with this pathway.
What type of drug is terbutaline?
Short-acting beta-2 adrenergic receptor agonist (SABA)
Also used as a bronchodilator in the treatment of asthma.
What type of drug is salmeterol?
Long-acting beta-2 adrenergic receptor agonist (LABA)
Used as a bronchodilator in the treatment of asthma.
What is the mechanism of action of magnesium sulfate in bronchodilation?
Interferes with calcium channels in smooth muscle, causing relaxation and bronchodilation
The exact mechanism is not fully understood.
What are the primary uses of magnesium sulfate in respiratory treatment?
Bronchodilation in the treatment of asthma
Evidence suggests its role in smooth muscle relaxation.
Fill in the blank: Theophylline is used to treat patients who are unresponsive to _______.
albuterol
True or False: Theophylline increases the sensitivity of the respiratory control center to pCO2.
True
