LeukotrieneSystInhibit, Antitussives, IL-5 R-Antag, PPI Flashcards
What is the difference between the two different kinds of leukotriene system inhibitors?
Zileuton is a LOX inhibitor (keukotriene synthesis inhibitor)
Montelukast is a leukotriene receptor antagonist
What class of drug is zileuton?
lipoxygenase inhibitor
leukotriene synthesis inhibitor
What is the mechanism of action of zileuton?
A lipoxygenase inhibitor that blocks the production of leukotrienes
Leads to decrease in leukotrienes.
What are the therapeutic uses or indications for zileuton?
Zileuton is used in the treatment of leukotriene mediated bronchoconstriction often associated with asthma and allergic responses.
What are the side effects of zileuton?
Liver injury, neuro/psychiatric effects
Zileuton inhibits the CYP that metabolizes theophylline, warfarin, and propanolol, increasing the levels of those drugs.
How can zileuton lead to drug interactions?
Zileuton inhibits the CYP that metabolizes theophylline, warfarin, and propanolol, increasing the levels of those drugs.
What type of drug is montelukast?
A selective leukotriene receptor antagonist
Montelukast decreases inflammatory responses and is used for leukotriene mediated bronchoconstriction associated with asthma and allergic responses.
What is the therapeutic use of montelukast (singulair)?
Montelukast decreases inflammatory responses and is used for leukotriene mediated bronchoconstriction associated with asthma and allergic responses.
Montelukast can reduce the amount of systemic corticosteroids needed.
What is the MoA of montelukast?
A selective leukotriene **receptor **antagonist for the immunomodulatory cells;
blocks the receptor to get a decrease in inflammatory responses.
What are the side effects of montelukast?
Neuro/psychiatric effects
Montelukast can reduce the amount of systemic corticosteroids needed.
What class of drug is codeine?
Opioid receptor agonist, but used as an antitussive.
What is the MoA of codeine?
Codeine is an opioid receptor agonist that suppresses activation of the cough center in the brain stem.
Opioid receptors also mediate suppression of the respiratory control center, sedation, drug addiction, and GI paralysis.
What is the primary use of codeine in medicine?
Suppress cough reflexes associated with non-productive coughs
Codeine is an opioid receptor agonist that suppresses activation of the cough center in the brain stem.
What type of drug is dextromethorphan?
Antitussive.
What is the mechanism of action of dextromethorphan?
Increases sensory threshold for airway obstruction activating the cough center
does not work on the cough center itself
But Dextromethorphan has shown NMDA receptor antagonist and sigma-1 receptor agonist activity.
Are antitussives used for a productive cough or nonproductive cough?
non-productive cough
Although the exact MoA is unknown with Dextromethorphan, what receptors is it an *agonist/antagonist *for?
Dextromethorphan has shown NMDA receptor **antagonist **
and
sigma-1 receptor agonist activity.
True or False: Dextromethorphan is non-addicting and has no respiratory suppression.
True.
It is also NOT a narcotic.
What class of drug is reslizumab?
IL-5 receptor antagonist.
Used for severe eosinophilic asthma.
What is the MoA of reslizumab in relation to its class and to eosinophils?
Eosinophils create Interleukin-5, but also activated by IL-5.
Reslizumab is an IL-5 receptor antagonist:
Because interleukin (IL)-5 is involved in eosinophil differentiation, maturation, recruitment, and activation, it has been identified as an important target for new biologics.”
What condition is reslizumab used to treat?
Severe eosinophilic asthma
Can substitute for oral glucocorticoids.
What drug class is omeprazole and how can it relate to respiratory?
Proton pump inhibitors (for asthma)
What is the action of proton pump inhibitors like omeprazole?
Directly inhibit proton pump on parietal cells
Omeprazole has a slow onset of action and is used in the treatment of PUD, gastritis, esophagitis, GERD, and esophageal bleeding.
What is the relationship between proton pump inhibitors and asthma?
PPIs alleviate asthma associated with GERD
Studies have shown that proton pump inhibitors can help in asthma cases related to gastroesophageal reflux disease.
